MeSH Browser

MeSH Heading: Oncogene Protein p21(ras)
Tree Number(s): D08.811.277.040.330.300.400.500.300; D12.776.157.325.515.500.300; D12.776.476.338.400.500.300; D12.776.624.664.520.750.710; D12.776.964.700.750.710; D12.776.964.775.750.710
Unique ID: D015689
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015689
Annotation: coord with specific virus
Scope Note: Transforming protein encoded by ras oncogenes. Point mutations in the cellular ras gene (c-ras) can also result in a mutant p21 protein that can transform mammalian cells. Oncogene protein p21(ras) has been directly implicated in human neoplasms, perhaps accounting for as much as 15-20% of all human tumors. This enzyme was formerly listed as EC 3.6.1.47.
Entry Term(s): p21 Transforming Viral Protein; p21 v-H-ras; p21 v-Ha-ras; p21 v-Ki-ras; p21 v-ras; p21(v-H-ras); p21(v-Ha-ras); p21(v-K-ras); p21(v-Ki-ras); ras Oncogene Product p21; ras Oncogene Protein p21; ras Oncogene p21 Product
Previous Indexing: Neoplasm Proteins (1980-1986); Oncogene Proteins, Viral (1986-1989)
Public MeSH Note: 1990
History Note: 1990
Date Established: 1990/01/01
Date of Entry: 1989/07/19
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Acid Anhydride Hydrolases [D08.811.277.040]
      - GTP Phosphohydrolases [D08.811.277.040.330]
        
        GTP-Binding Proteins [D08.811.277.040.330.300]
        
        Monomeric GTP-Binding Proteins [D08.811.277.040.330.300.400]
        
        ras Proteins [D08.811.277.040.330.300.400.500]
        
        Oncogene Protein p21(ras) [D08.811.277.040.330.300.400.500.300]
        
        Proto-Oncogene Proteins p21(ras) [D08.811.277.040.330.300.400.500.600]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - GTP-Binding Proteins [D12.776.157.325]
      - Monomeric GTP-Binding Proteins [D12.776.157.325.515]
        
        ras Proteins [D12.776.157.325.515.500]
        
        Oncogene Protein p21(ras) [D12.776.157.325.515.500.300]
        
        Proto-Oncogene Proteins p21(ras) [D12.776.157.325.515.500.600]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - GTP-Binding Proteins [D12.776.476.338]
      - Monomeric GTP-Binding Proteins [D12.776.476.338.400]
        
        ras Proteins [D12.776.476.338.400.500]
        
        Oncogene Protein p21(ras) [D12.776.476.338.400.500.300]
        
        Proto-Oncogene Proteins p21(ras) [D12.776.476.338.400.500.600]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Neoplasm Proteins [D12.776.624]
    - Oncogene Proteins [D12.776.624.664]
      - Oncogene Proteins, Viral [D12.776.624.664.520]
        
        Retroviridae Proteins, Oncogenic [D12.776.624.664.520.750]
        
        Fusion Proteins, gag-onc [D12.776.624.664.520.750.320]
        
        Gene Products, rex [D12.776.624.664.520.750.470]
        
        Gene Products, tax [D12.776.624.664.520.750.480]
        
        Oncogene Protein gp140(v-fms) [D12.776.624.664.520.750.650]
        
        Oncogene Protein p21(ras) [D12.776.624.664.520.750.710]
        
        Oncogene Protein p55(v-myc) [D12.776.624.664.520.750.750]
        
        Oncogene Protein pp60(v-src) [D12.776.624.664.520.750.760]
        
        Oncogene Protein v-akt [D12.776.624.664.520.750.788]
        
        Oncogene Protein v-cbl [D12.776.624.664.520.750.817]
        
        Oncogene Protein v-crk [D12.776.624.664.520.750.846]
        
        Oncogene Protein v-maf [D12.776.624.664.520.750.860]
        
        Oncogene Proteins v-abl [D12.776.624.664.520.750.875]
        
        Oncogene Proteins v-erbA [D12.776.624.664.520.750.882]
        
        Oncogene Proteins v-erbB [D12.776.624.664.520.750.883]
        
        Oncogene Proteins v-fos [D12.776.624.664.520.750.887]
        
        Oncogene Proteins v-mos [D12.776.624.664.520.750.900]
        
        Oncogene Proteins v-myb [D12.776.624.664.520.750.903]
        
        Oncogene Proteins v-raf [D12.776.624.664.520.750.920]
        
        Oncogene Proteins v-rel [D12.776.624.664.520.750.925]
        
        Oncogene Proteins v-sis [D12.776.624.664.520.750.935]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Viral Proteins [D12.776.964]
    - Oncogene Proteins, Viral [D12.776.964.700]
      - Retroviridae Proteins, Oncogenic [D12.776.964.700.750]
        
        Fusion Proteins, gag-onc [D12.776.964.700.750.320]
        
        Gene Products, rex [D12.776.964.700.750.470]
        
        Gene Products, tax [D12.776.964.700.750.480]
        
        Oncogene Protein gp140(v-fms) [D12.776.964.700.750.650]
        
        Oncogene Protein p21(ras) [D12.776.964.700.750.710]
        
        Oncogene Protein p55(v-myc) [D12.776.964.700.750.750]
        
        Oncogene Protein pp60(v-src) [D12.776.964.700.750.760]
        
        Oncogene Protein v-maf [D12.776.964.700.750.817]
        
        Oncogene Proteins v-abl [D12.776.964.700.750.875]
        
        Oncogene Proteins v-erbA [D12.776.964.700.750.882]
        
        Oncogene Proteins v-erbB [D12.776.964.700.750.883]
        
        Oncogene Proteins v-fos [D12.776.964.700.750.887]
        
        Oncogene Proteins v-mos [D12.776.964.700.750.900]
        
        Oncogene Proteins v-myb [D12.776.964.700.750.903]
        
        Oncogene Proteins v-raf [D12.776.964.700.750.920]
        
        Oncogene Proteins v-rel [D12.776.964.700.750.925]
        
        Oncogene Proteins v-sis [D12.776.964.700.750.935]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Viral Proteins [D12.776.964]
    - Retroviridae Proteins [D12.776.964.775]
      - Retroviridae Proteins, Oncogenic [D12.776.964.775.750]
        
        Fusion Proteins, gag-onc [D12.776.964.775.750.320]
        
        Gene Products, rex [D12.776.964.775.750.470]
        
        Gene Products, tax [D12.776.964.775.750.480]
        
        Oncogene Protein gp140(v-fms) [D12.776.964.775.750.650]
        
        Oncogene Protein p21(ras) [D12.776.964.775.750.710]
        
        Oncogene Protein p55(v-myc) [D12.776.964.775.750.750]
        
        Oncogene Protein pp60(v-src) [D12.776.964.775.750.760]
        
        Oncogene Protein v-maf [D12.776.964.775.750.817]
        
        Oncogene Proteins v-abl [D12.776.964.775.750.875]
        
        Oncogene Proteins v-erbA [D12.776.964.775.750.882]
        
        Oncogene Proteins v-erbB [D12.776.964.775.750.883]
        
        Oncogene Proteins v-fos [D12.776.964.775.750.887]
        
        Oncogene Proteins v-mos [D12.776.964.775.750.900]
        
        Oncogene Proteins v-myb [D12.776.964.775.750.903]
        
        Oncogene Proteins v-raf [D12.776.964.775.750.920]
        
        Oncogene Proteins v-rel [D12.776.964.775.750.925]
        
        Oncogene Proteins v-sis [D12.776.964.775.750.935]

Oncogene Protein p21(ras) Preferred

Concept UI: M0024065
Scope Note: Transforming protein encoded by ras oncogenes. Point mutations in the cellular ras gene (c-ras) can also result in a mutant p21 protein that can transform mammalian cells. Oncogene protein p21(ras) has been directly implicated in human neoplasms, perhaps accounting for as much as 15-20% of all human tumors. This enzyme was formerly listed as EC 3.6.1.47.
Terms: Oncogene Protein p21(ras) Preferred Term
Term UI T046491
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1990); p21 Transforming Viral Protein
Term UI T046492
Date02/10/1989
LexicalTag NON
ThesaurusID NLM (1990); p21 v-H-ras
Term UI T046493
Date04/04/1990
LexicalTag NON
ThesaurusID NLM (1991); p21(v-H-ras)
Term UI T046494
Date04/04/1990
LexicalTag NON
ThesaurusID NLM (1991); p21 v-Ki-ras
Term UI T046495
Date04/04/1990
LexicalTag NON
ThesaurusID NLM (1991); p21(v-Ki-ras)
Term UI T046496
Date04/04/1990
LexicalTag NON
ThesaurusID NLM (1991); ras Oncogene p21 Product
Term UI T046497
Date02/10/1989
LexicalTag NON
ThesaurusID NLM (1990); ras Oncogene Product p21
Term UI T046498
Date02/10/1989
LexicalTag NON
ThesaurusID NLM (1990); p21 v-Ha-ras
Term UI T046499
Date04/04/1990
LexicalTag NON
ThesaurusID NLM (1991); p21(v-Ha-ras)
Term UI T046500
Date04/04/1990
LexicalTag NON
ThesaurusID NLM (1991); p21(v-K-ras)
Term UI T046501
Date04/04/1990
LexicalTag NON
ThesaurusID NLM (1991); ras Oncogene Protein p21
Term UI T046490
Date05/08/1989
LexicalTag NON
ThesaurusID NLM (1990); p21 v-ras
Term UI T046502
Date04/03/1990
LexicalTag NON
ThesaurusID NLM (1991)

Oncogene Protein p21(ras) MeSH Descriptor Data 2024