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Oncogene Protein gp140(v-fms) MeSH Descriptor Data 2022


MeSH Heading
Oncogene Protein gp140(v-fms)
Tree Number(s)
D12.776.624.664.520.750.650
D12.776.964.700.750.650
D12.776.964.775.750.650
Unique ID
D016281
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D016281
Annotation
IM; coord with specific virus (IM); /‌drug eff /‌ultrastruct permitted
Scope Note
Transforming glycoprotein coded by the fms oncogene from the Susan McDonough strain of feline sarcoma virus (SM-FeSV). The oncogene protein v-fms lacks sequences, which, in the highly homologous proto-oncogene protein c-fms (CSF-1 receptor), normally serve to regulate its tyrosine kinase activity. The missing sequences in v-fms mimic the effect of ligand and lead to constitutive cell growth. The protein gp120(v-fms) is post-translationally modified to generate gp140(v-fms).
Entry Term(s)
fms Oncogene Product gp120
fms Oncogene Product gp140
fms Oncogene Protein gp120
fms Oncogene Protein gp140
gp120 v-fms
gp120(v-fms)
gp140 v-fms
gp140(v-fms)
v-fms Protein
Registry Number
0
Previous Indexing
Oncogene Proteins, Viral (1985-1989)
Retroviridae Proteins (1987-1989)
Retroviridae Proteins, Oncogenic (1990)
Public MeSH Note
91
History Note
91
Date Established
1991/01/01
Date of Entry
1990/06/19
Revision Date
2019/05/24
Oncogene Protein gp140(v-fms) Preferred
fms Oncogene Protein gp120 Narrower
gp120(v-fms) Narrower
fms Oncogene Product gp120 Narrower
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