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Oncogene Proteins v-erbA MeSH Descriptor Data 2022


MeSH Heading
Oncogene Proteins v-erbA
Tree Number(s)
D12.776.624.664.520.750.882
D12.776.964.700.750.882
D12.776.964.775.750.882
Unique ID
D018774
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D018774
Scope Note
Transforming proteins encoded by erbA oncogenes from the avian erythroblastosis virus. They are truncated versions of c-erbA, the thyroid hormone receptor (RECEPTORS, THYROID HORMONE) that have retained both the DNA-binding and hormone-binding domains. Mutations in the hormone-binding domains abolish the transcriptional activation function. v-erbA acts as a dominant repressor of c-erbA, inducing transformation by disinhibiting proliferation.
Entry Term(s)
Oncogene Products v-erbA
erbA Oncogene Proteins
v-erbA Proteins
Registry Number
0
Previous Indexing
Retroviridae Proteins (1987-1989)
Retroviridae Proteins, Oncogenic (1990-1994)
Public MeSH Note
95; ONCOGENE PROTEIN ERBA was indexed under RETROVIRIDAE PROTEINS, ONCOGENIC 1990-94 & RETROVIRIDAE PROTEINS 1987-89
Online Note
use ONCOGENE PROTEINS V-ERBA (NM) to search ONCOGENE PROTEIN ERBA 1987-94
History Note
95; was ONCOGENE PROTEIN ERBA (NM) 1987-94
Date Established
1995/01/01
Date of Entry
1994/05/23
Revision Date
2018/07/01
Oncogene Proteins v-erbA Preferred
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