MeSH Browser

MeSH Heading: Mice, SCID
Tree Number(s): B01.050.150.900.649.313.992.635.505.500.550.780
Unique ID: D016513
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016513
Annotation: NIM with no qualifiers when experimental animal
Scope Note: Mice homozygous for the mutant autosomal recessive gene scid which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Entry Term(s): Immunodeficient Mice, Severe Combined; Mouse, SCID; Mouse, SCID-hu; SCID Mice; SCID-hu Mice; Severe Combined Immunodeficient Mice
Previous Indexing: Mice, Mutant Strains (1983-1991)
Public MeSH Note: 92
History Note: 92
Date Established: 1992/01/01
Date of Entry: 1991/01/03
Revision Date: 2020/09/02

Allowable Qualifiers: abnormalities (AB)

anatomy & histology (AH)

blood (BL)

cerebrospinal fluid (CF)

classification (CL)

embryology (EM)

genetics (GE)

growth & development (GD)

immunology (IM)

injuries (IN)

metabolism (ME)

microbiology (MI)

parasitology (PS)

physiology (PH)

psychology (PX)

surgery (SU)

urine (UR)

virology (VI)

Concept UI: M0025206
Scope Note: Mice homozygous for the mutant autosomal recessive gene scid which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Terms: Mice, SCID Preferred Term
Term UI T049390
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1992); Immunodeficient Mice, Severe Combined
Term UI T049386
Date10/24/1990
LexicalTag NON
ThesaurusID NLM (1992); Severe Combined Immunodeficient Mice
Term UI T049387
Date08/27/1990
LexicalTag NON
ThesaurusID NLM (1992); Mouse, SCID
Term UI T049388
Date08/27/1990
LexicalTag NON
ThesaurusID NLM (1992); SCID Mice
Term UI T049389
Date08/28/1990
LexicalTag NON
ThesaurusID NLM (1992)

Mice, SCID MeSH Descriptor Data 2024