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Mice, SCID MeSH Descriptor Data 2022


MeSH Heading
Mice, SCID
Tree Number(s)
B01.050.150.900.649.313.992.635.505.500.550.780
Unique ID
D016513
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D016513
Annotation
NIM with no qualifiers when experimental animal
Scope Note
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Entry Term(s)
Immunodeficient Mice, Severe Combined
Mouse, SCID
Mouse, SCID-hu
SCID Mice
SCID-hu Mice
Severe Combined Immunodeficient Mice
Previous Indexing
Mice, Mutant Strains (1983-1991)
Public MeSH Note
92
History Note
92
Date Established
1992/01/01
Date of Entry
1991/01/03
Revision Date
2020/09/02
Mice, SCID Preferred
Mouse, SCID-hu Related
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