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Mice, Knockout MeSH Descriptor Data 2022


MeSH Heading
Mice, Knockout
Tree Number(s)
B01.050.050.136.500.500
B01.050.150.900.649.313.992.635.505.500.550.455
B01.050.150.900.649.313.992.635.505.500.800.500
Unique ID
D018345
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D018345
Annotation
NIM no qualif when exper animal; do not forget also to check MICE
Scope Note
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Entry Term(s)
Knockout Mice
Mice, Knock-out
Mouse, Knockout
Previous Indexing
Mice (1992-1993)
See Also
Gene Knockout Techniques
Public MeSH Note
94
History Note
94
Date Established
1994/01/01
Date of Entry
1993/06/03
Revision Date
2020/09/02
Mice, Knockout Preferred
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