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Myasthenia Gravis, Autoimmune, Experimental MeSH Descriptor Data 2025
Any autoimmune animal disease model used in the study of MYASTHENIA GRAVIS. Injection with purified neuromuscular junction acetylcholine receptor (AChR) (see RECEPTORS, CHOLINERGIC) components results in a myasthenic syndrome that has acute and chronic phases. The motor endplate pathology, loss of acetylcholine receptors, presence of circulating anti-AChR antibodies, and electrophysiologic changes make this condition virtually identical to human myasthenia gravis. Passive transfer of AChR antibodies or lymphocytes from afflicted animals to normals induces passive transfer experimental autoimmune myasthenia gravis. (From Joynt, Clinical Neurology, 1997, Ch 54, p3)
Entry Term(s)
Autoimmune Experimental Myasthenia Gravis
Experimental Autoimmune Myasthenia Gravis, Passive Transfer
Experimental Myasthenia
Experimental Myasthenia Gravis
Myasthenia Gravis, Autoimmune Experimental
Myasthenia Gravis, Experimental Autoimmune
Passive Transfer Experimental Autoimmune Myasthenia Gravis
Previous Indexing
Autoimmune Diseases (1969-1999)
Myasthenia Gravis (1968-1999)
Public MeSH Note
2005; see MYASTHENIA GRAVIS, EXPERIMENTAL AUTOIMMUNE 2000-2004
Any autoimmune animal disease model used in the study of MYASTHENIA GRAVIS. Injection with purified neuromuscular junction acetylcholine receptor (AChR) (see RECEPTORS, CHOLINERGIC) components results in a myasthenic syndrome that has acute and chronic phases. The motor endplate pathology, loss of acetylcholine receptors, presence of circulating anti-AChR antibodies, and electrophysiologic changes make this condition virtually identical to human myasthenia gravis. Passive transfer of AChR antibodies or lymphocytes from afflicted animals to normals induces passive transfer experimental autoimmune myasthenia gravis. (From Joynt, Clinical Neurology, 1997, Ch 54, p3)