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Poly(A)-Binding Protein II MeSH Descriptor Data 2023


MeSH Heading
Poly(A)-Binding Protein II
Tree Number(s)
D12.776.157.725.452.500
D12.776.664.962.452.500
Unique ID
D039103
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D039103
Scope Note
A poly(A) binding protein that is involved in promoting the extension of the poly A tails of MRNA. The protein requires a minimum of ten ADENOSINE nucleotides in order for binding to mRNA. Once bound it works in conjunction with CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR to stimulate the rate of poly A synthesis by POLY A POLYMERASE. Once poly-A tails reach around 250 nucleotides in length poly(A) binding protein II no longer stimulates POLYADENYLATION. Mutations within a GCG repeat region in the gene for poly(A) binding protein II have been shown to cause the disease MUSCULAR DYSTROPHY, OCULOPHARYNGEAL.
Entry Term(s)
PAB II
PAB2 Poly(A) Binding Protein
PABP2
Pabp2 Gene Product
Pabp2 Protein
Poly(A) Binding Protein II
Poly(A) Binding Protein, Nuclear 1
Registry Number
0
Previous Indexing
RNA-Binding Proteins (1995-2002)
See Also
Muscular Dystrophy, Oculopharyngeal
Public MeSH Note
2003; PAB II was indexed under RNA-BINDING PROTEINS 1995-2002; PABP2 GENE PRODUCT & PABP2 PROTEIN were indexed under RNA-BINDING PROTEINS 1999-2002; PABP2 was indexed under RNA-BINDING PROTEINS 2000-2002
History Note
2003; for PAB II use POLY(A)-BINDING PROTEINS (NM) 1995-2002; for PABP2 GENE PRODUCT & PABP2 PROTEIN use POLY(A)-BINDING PROTEINS (NM) 1999-2002; for PABP2 use POLY(A)-BINDING PROTEINS (NM) 2000-2002
Date Established
2003/01/01
Date of Entry
2002/07/03
Poly(A)-Binding Protein II Preferred
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