- Concept UI
- M0232435
- Registry Number
- EC 3.1.3.48
- Scope Note
- A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of a N-terminal catalytic domain and a large C-terminal domain that is enriched in PROLINE, GLUTAMIC ACID, SERINE, and THREONINE residues (PEST sequences). The phosphatase subtype is ubiquitously expressed and implicated in the regulation of a variety of biological processes such as CELL MOVEMENT; CYTOKINESIS; focal adhesion disassembly; and LYMPHOCYTE ACTIVATION.
- Terms
-
Protein Tyrosine Phosphatase, Non-Receptor Type 12
Preferred Term
Term UI
T690125
Date01/26/2007
LexicalTag
NON
ThesaurusID
NLM (2008)
-
PEST-Enriched Phosphatase
Term UI
T262438
LexicalTag
ABX
ThesaurusID
NLM (2008)
-
PEP Protein Tyrosine Phosphatase
Term UI
T262440
LexicalTag
ABX
ThesaurusID
NLM (2008)
-
PEP PTPase
Term UI
T262437
LexicalTag
ABX
ThesaurusID
NLM (2008)
-
PTP-PEST
Term UI
T262439
LexicalTag
ABB
ThesaurusID
NLM (2008)