MeSH Browser

MeSH Heading: Protein Tyrosine Phosphatase, Non-Receptor Type 12
Tree Number(s): D08.811.277.352.650.775.300.850; D12.776.476.564.300.850
Unique ID: D054594
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D054594
Scope Note: A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of a N-terminal catalytic domain and a large C-terminal domain that is enriched in PROLINE, GLUTAMIC ACID, SERINE, and THREONINE residues (PEST sequences). The phosphatase subtype is ubiquitously expressed and implicated in the regulation of a variety of biological processes such as CELL MOVEMENT; CYTOKINESIS; focal adhesion disassembly; and LYMPHOCYTE ACTIVATION.
Entry Term(s): PEP PTPase; PEP Protein Tyrosine Phosphatase; PEST-Enriched Phosphatase; PTP-PEST
Public MeSH Note: 2008; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 12 was indexed under PROTEIN TYROSINE PHOSPHATASE 1994-2007
History Note: 2008(1994)
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0232435
Scope Note: A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of a N-terminal catalytic domain and a large C-terminal domain that is enriched in PROLINE, GLUTAMIC ACID, SERINE, and THREONINE residues (PEST sequences). The phosphatase subtype is ubiquitously expressed and implicated in the regulation of a variety of biological processes such as CELL MOVEMENT; CYTOKINESIS; focal adhesion disassembly; and LYMPHOCYTE ACTIVATION.
Terms: Protein Tyrosine Phosphatase, Non-Receptor Type 12 Preferred Term
Term UI T690125
Date01/26/2007
LexicalTag NON
ThesaurusID NLM (2008); PEST-Enriched Phosphatase
Term UI T262438
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2008); PTP-PEST
Term UI T262439
Date01/01/1955
LexicalTag ABB
ThesaurusID NLM (2008); PEP Protein Tyrosine Phosphatase
Term UI T262440
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2008); PEP PTPase
Term UI T262437
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2008)

Protein Tyrosine Phosphatase, Non-Receptor Type 12 MeSH Descriptor Data 2024