MeSH Browser

MeSH Heading: Cholera Toxin
Tree Number(s): D08.811.913.400.725.115.180; D23.946.123.194; D23.946.330.150
Unique ID: D002772
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D002772
Annotation: /antag permitted but consider also ANTITOXINS
Scope Note: An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
Entry Term(s): Cholera Enterotoxin CT; Cholera Exotoxin; Cholera Toxin A; Cholera Toxin A Subunit; Cholera Toxin B; Cholera Toxin B Subunit; Cholera Toxin Protomer A; Cholera Toxin Protomer B; Cholera Toxin Subunit A; Cholera Toxin Subunit B; Choleragen; Choleragenoid; Procholeragenoid
Pharm Action: Adjuvants, Immunologic
Poisons
Related Numbers: EC 2.4.2.31
NLM Classification #: WC 262
Previous Indexing: Bacterial Proteins (1966-1977); Bacterial Toxins (1977); Enterotoxins (1966-1977); Toxins (1966-1967)
Public MeSH Note: 78
History Note: 78
Date Established: 1978/01/01
Date of Entry: 1977/04/22
Revision Date: 2021/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Glycosyltransferases [D08.811.913.400]
      - Pentosyltransferases [D08.811.913.400.725]
        
        ADP Ribose Transferases [D08.811.913.400.725.115]
        
        Cholera Toxin [D08.811.913.400.725.115.180]
        
        Diphtheria Toxin [D08.811.913.400.725.115.220]
        
        NAD+ Nucleosidase [D08.811.913.400.725.115.660]
        
        Pertussis Toxin [D08.811.913.400.725.115.680]
        
        Poly(ADP-ribose) Polymerases [D08.811.913.400.725.115.690]
        
        Pseudomonas aeruginosa Exotoxin A [D08.811.913.400.725.115.826]
        
        Sirtuins [D08.811.913.400.725.115.961]

Biological Factors [D23]
- Toxins, Biological [D23.946]
  - Bacterial Toxins [D23.946.123]

Biological Factors [D23]
- Toxins, Biological [D23.946]
  - Enterotoxins [D23.946.330]
    - Cholera Toxin [D23.946.330.150]
    - Shiga Toxins [D23.946.330.575]

Cholera Toxin Preferred

Concept UI: M0004245
Related Numbers: EC 2.4.2.31
Scope Note: An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
Terms: Cholera Toxin Preferred Term
Term UI T008049
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1978); Cholera Enterotoxin CT
Term UI T479389
Date01/25/2002
LexicalTag NON
ThesaurusID NLM (2003); Cholera Exotoxin
Term UI T008048
Date09/19/1984
LexicalTag NON
ThesaurusID UNK (19XX); Choleragen
Term UI T008053
Date04/20/1977
LexicalTag NON
ThesaurusID UNK (19XX)

Choleragenoid Narrower

Concept UI: M0004246
Scope Note: The nontoxic, pentameric B protomer of cholera toxin. The cell membrane binding component of cholera toxin.
Terms: Choleragenoid Preferred Term
Term UI T008051
Date04/20/1977
LexicalTag NON
ThesaurusID UNK (19XX); Cholera Toxin Subunit B
Term UI T001006312
Date01/28/2020
LexicalTag NON
ThesaurusID NLM (2021); Cholera Toxin B
Term UI T001006309
Date01/28/2020
LexicalTag NON
ThesaurusID NLM (2021); Cholera Toxin B Subunit
Term UI T008050
Date09/16/1983
LexicalTag NON
ThesaurusID UNK (19XX); Cholera Toxin Protomer B
Term UI T479388
Date01/25/2002
LexicalTag NON
ThesaurusID NLM (2003)

Cholera Toxin Protomer A Narrower

Concept UI: M0004247
Scope Note: The catalytic subunit of cholera toxin. It is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE.
Terms: Cholera Toxin Protomer A Preferred Term
Term UI T008052
Date02/23/1983
LexicalTag NON
ThesaurusID UNK (19XX); Cholera Toxin Subunit A
Term UI T001006311
Date01/28/2020
LexicalTag NON
ThesaurusID NLM (2021); Cholera Toxin A
Term UI T001006310
Date01/28/2020
LexicalTag NON
ThesaurusID NLM (2021); Cholera Toxin A Subunit
Term UI T479390
Date01/25/2002
LexicalTag NON
ThesaurusID NLM (2003)

Procholeragenoid Narrower

Cholera Toxin MeSH Descriptor Data 2024