MeSH Browser

MeSH Heading: DNA Glycosylases
Tree Number(s): D08.811.074.249; D08.811.277.450.430.099
Unique ID: D045647
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D045647
Scope Note: A family of DNA repair enzymes that recognize damaged nucleotide bases and remove them by hydrolyzing the N-glycosidic bond that attaches them to the sugar backbone of the DNA molecule. The process called BASE EXCISION REPAIR can be completed by a DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE which excises the remaining RIBOSE sugar from the DNA.
Entry Term(s): DNA Glycosylase; DNA N-glycosidase; Methylpurine DNA Glycosylase
Registry Numbers: EC 3.2.2.-; EC 3.2.2.-
Previous Indexing: DNA (1978-1981); Glycoside Hydrolases (1978-1981); N-Glycosyl Hydrolases (1982-2003)
Public MeSH Note: 2004; DNA GLYCOSIDASES was indexed under N-GLYCOSIDE HYDROLASES 1982-2003, under GLYCOSIDE HYDROLASES & DNA 1978-1981
History Note: 2004; use DNA GLYCOSIDASES (NM) 1980-2003
Date Established: 2004/01/01
Date of Entry: 2003/07/09
Revision Date: 2006/07/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0073348
Registry Numbers: EC 3.2.2.-
Scope Note: A family of DNA repair enzymes that recognize damaged nucleotide bases and remove them by hydrolyzing the N-glycosidic bond that attaches them to the sugar backbone of the DNA molecule. The process called BASE EXCISION REPAIR can be completed by a DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE which excises the remaining RIBOSE sugar from the DNA.
Terms: DNA Glycosylases Preferred Term
Term UI T539784
Date05/02/2003
LexicalTag ABX
ThesaurusID NLM (2004); DNA Glycosylase
Term UI T103351
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2004); DNA N-glycosidase
Term UI T103353
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2004)

DNA Glycosylases MeSH Descriptor Data 2025