MeSH Browser

MeSH Heading: Frameshift Mutation
Tree Number(s): G05.365.590.265
Unique ID: D016368
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016368
Annotation: do not confuse with FRAMESHIFTING, RIBOSOMAL, physiology process & form of genetic translation; do not confuse effects of drug & radiation on frameshift mutation with drug- & radiation-induced frameshift mutation
Scope Note: A type of mutation in which a number of NUCLEOTIDES deleted from or inserted into a protein coding sequence is not divisible by three, thereby causing an alteration in the READING FRAMES of the entire coding sequence downstream of the mutation. These mutations may be induced by certain types of MUTAGENS or may occur spontaneously.
Entry Term(s): Frame Shift Mutation; Mutation, Frameshift; Out-of-Frame Deletion; Out-of-Frame Insertion; Out-of-Frame Mutation
Previous Indexing: Mutation (1968-1990)
Public MeSH Note: 91
History Note: 91
Date Established: 1991/01/01
Date of Entry: 1990/05/25
Revision Date: 2008/07/08

Allowable Qualifiers: drug effects (DE)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Concept UI: M0025037
Scope Note: A type of mutation in which a number of NUCLEOTIDES deleted from or inserted into a protein coding sequence is not divisible by three, thereby causing an alteration in the READING FRAMES of the entire coding sequence downstream of the mutation. These mutations may be induced by certain types of MUTAGENS or may occur spontaneously.
Terms: Frameshift Mutation Preferred Term
Term UI T048910
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1991); Frame Shift Mutation
Term UI T048911
Date04/24/1990
LexicalTag NON
ThesaurusID NLM (1991); Mutation, Frameshift
Term UI T048909
Date02/26/1992
LexicalTag NON
ThesaurusID NLM (1993); Out-of-Frame Mutation
Term UI T606242
Date08/26/2004
LexicalTag NON
ThesaurusID NLM (2006)

Frameshift Mutation MeSH Descriptor Data 2024