MeSH Browser

MeSH Heading: Poly(ADP-ribose) Polymerases
Tree Number(s): D08.811.913.400.725.115.690
Unique ID: D011065
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D011065
Scope Note: Enzymes that catalyze the transfer of multiple ADP-RIBOSE groups from nicotinamide-adenine dinucleotide (NAD) onto protein targets, thus building up a linear or branched homopolymer of repeating ADP-ribose units i.e., POLY ADENOSINE DIPHOSPHATE RIBOSE.
Entry Term(s): ADP-Ribosyltransferase (Polymerizing); PARP Polymerase; Poly ADP Ribose Polymerase; Poly ADP Ribose Transferase; Poly ADP-Ribose Synthase; Poly(ADP-Ribose) Synthase; Poly(ADP-Ribose) Transferase; Poly(ADP-ribose) Polymerase; Poly(ADPR) Polymerase; Poly(ADPribose) Polymerase
Registry Number: EC 2.4.2.30
Related Numbers: 58319-92-9
CAS Type 1 Name: NAD+:poly(adenosine diphosphate D-ribose)-acceptor ADP-D-ribosyltransferase
Previous Indexing: NAD Nucleosidase (1975-1976); Nucleosidases (1966-1974)
See Also: Poly ADP Ribosylation
Public MeSH Note: 2003; see NAD+ ADP-RIBOSYLTRANSFERASE 1992-2002, see POLY ADP RIBOSE POLYMERASE 1977-1991, see NAD NUCLEOSIDASE 1975-1976
History Note: 2003 (1977); use NAD NUCLEOSIDASE 1975-1976
Entry Combination: antagonists & inhibitors:Poly(ADP-ribose) Polymerase Inhibitors
Date Established: 1986/01/01
Date of Entry: 1976/04/19
Revision Date: 2019/07/01

Entry Combination: antagonists & inhibitors:Poly(ADP-ribose) Polymerase Inhibitors
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Glycosyltransferases [D08.811.913.400]
      - Pentosyltransferases [D08.811.913.400.725]
        
        ADP Ribose Transferases [D08.811.913.400.725.115]
        
        Cholera Toxin [D08.811.913.400.725.115.180]
        
        Diphtheria Toxin [D08.811.913.400.725.115.220]
        
        NAD+ Nucleosidase [D08.811.913.400.725.115.660]
        
        Pertussis Toxin [D08.811.913.400.725.115.680]
        
        Poly(ADP-ribose) Polymerases [D08.811.913.400.725.115.690]
        
        Poly (ADP-Ribose) Polymerase-1 [D08.811.913.400.725.115.690.420]
        
        Tankyrases [D08.811.913.400.725.115.690.840]
        
        Pseudomonas aeruginosa Exotoxin A [D08.811.913.400.725.115.826]
        
        Sirtuins [D08.811.913.400.725.115.961]

Poly(ADP-ribose) Polymerases Preferred

Concept UI: M0017141
Registry Number: EC 2.4.2.30
Related Numbers: 58319-92-9
Scope Note: Enzymes that catalyze the transfer of multiple ADP-RIBOSE groups from nicotinamide-adenine dinucleotide (NAD) onto protein targets, thus building up a linear or branched homopolymer of repeating ADP-ribose units i.e., POLY ADENOSINE DIPHOSPHATE RIBOSE.
Terms: Poly(ADP-ribose) Polymerases Preferred Term
Term UI T475372
Date12/31/2001
LexicalTag ACX
ThesaurusID NLM (2003); ADP-Ribosyltransferase (Polymerizing)
Term UI T032535
Date03/23/1987
LexicalTag NON
ThesaurusID UNK (19XX); Poly(ADP-ribose) Polymerase
Term UI T032536
Date12/24/1997
LexicalTag ACX
ThesaurusID NLM (1999); Poly ADP Ribose Polymerase
Term UI T032537
Date12/14/1990
LexicalTag NON
ThesaurusID NLM (1992); Poly(ADP-Ribose) Transferase
Term UI T481790
Date02/13/2002
LexicalTag ACX
ThesaurusID NLM (2003); Poly(ADP-Ribose) Synthase
Term UI T032541
Date09/22/1992
LexicalTag NON
ThesaurusID NLM (1994); PARP Polymerase
Term UI T471640
Date11/30/2001
LexicalTag ACX
ThesaurusID NLM (2003); Poly(ADPribose) Polymerase
Term UI T475402
Date12/31/2001
LexicalTag ACX
ThesaurusID NLM (2003); Poly ADP-Ribose Synthase
Term UI T481789
Date02/13/2002
LexicalTag ACX
ThesaurusID NLM (2003); Poly(ADPR) Polymerase
Term UI T475403
Date12/31/2001
LexicalTag ACX
ThesaurusID NLM (2003); Poly ADP Ribose Transferase
Term UI T032538
Date08/13/1987
LexicalTag NON
ThesaurusID UNK (19XX)

Poly(ADP-ribose) Polymerases MeSH Descriptor Data 2024