MeSH Browser

MeSH Heading: Pro-Opiomelanocortin
Tree Number(s): D06.472.699.327.935; D06.472.699.631.525.600; D12.644.400.400.935; D12.644.548.365.935; D12.644.548.691.525.690; D12.776.631.650.405.935; D12.776.811.800
Unique ID: D011333
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D011333
Scope Note: A 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral tissues. Depending on species and tissues, POMC is cleaved by PROHORMONE CONVERTASES yielding various active peptides including ACTH; BETA-LIPOTROPIN; ENDORPHINS; MELANOCYTE-STIMULATING HORMONES; and others (GAMMA-LPH; CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE; N-terminal peptide of POMC or NPP).
Entry Term(s): ACTH-Endorphin Precursor; ACTH-beta-Lipotropin Precursor; Corticotropin-beta-Lipotropin Precursor; Endorphin-ACTH Precursor; Opiocortin; POMC; Pre-POMC; Pre-pro-opiocortin; Preproopiomelanocortin; Pro-ACTH-Endorphin; Pro-Opio-Melanocortin; Pro-Opiocortin; Proopiocortin; Proopiomelanocortin
Related Numbers: 76775-14-9; 78321-08-1
CAS Type 1 Name: Opiomelanocortin, pro-
Previous Indexing: Pituitary Hormones, Anterior (1966-1984); Protein Precursors (1973-1984)
Public MeSH Note: 1985; PRE-PRO-OPIOCORTIN was indexed under PRO-OPIOMELANOCORTIN & PROTEIN PRECURSORS 1980-2007; OPIOCORTIN was indexed under PRO-OPIOMELANOCORTIN 1987-2007
History Note: 1985
Date Established: 1985/01/01
Date of Entry: 1984/05/30
Revision Date: 2015/11/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
- Hormones [D06.472]
  - Peptide Hormones [D06.472.699]
    - Hypothalamic Hormones [D06.472.699.327]

Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
- Hormones [D06.472]
  - Peptide Hormones [D06.472.699]
    - Pituitary Hormones [D06.472.699.631]
      - Pituitary Hormones, Anterior [D06.472.699.631.525]
        
        Gonadotropins, Pituitary [D06.472.699.631.525.343]
        
        Growth Hormone [D06.472.699.631.525.425]
        
        Prolactin [D06.472.699.631.525.525]
        
        Pro-Opiomelanocortin [D06.472.699.631.525.600]
        
        alpha-Endorphin [D06.472.699.631.525.600.119]
        
        alpha-MSH [D06.472.699.631.525.600.179]
        
        beta-Endorphin [D06.472.699.631.525.600.239]
        
        beta-Lipotropin [D06.472.699.631.525.600.480]
        
        Corticotropin-Like Intermediate Lobe Peptide [D06.472.699.631.525.600.498]
        
        gamma-Endorphin [D06.472.699.631.525.600.505]
        
        gamma-Lipotropin [D06.472.699.631.525.600.518]
        
        gamma-MSH [D06.472.699.631.525.600.524]
        
        Melanocortins [D06.472.699.631.525.600.531]
        
        Thyrotropin [D06.472.699.631.525.883]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Neuropeptides [D12.644.400]
    - Hypothalamic Hormones [D12.644.400.400]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Peptide Hormones [D12.644.548]
    - Hypothalamic Hormones [D12.644.548.365]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Peptide Hormones [D12.644.548]
    - Pituitary Hormones [D12.644.548.691]
      - Pituitary Hormones, Anterior [D12.644.548.691.525]
        
        Gonadotropins, Pituitary [D12.644.548.691.525.343]
        
        Growth Hormone [D12.644.548.691.525.425]
        
        Prolactin [D12.644.548.691.525.525]
        
        Pro-Opiomelanocortin [D12.644.548.691.525.690]
        
        alpha-Endorphin [D12.644.548.691.525.690.119]
        
        alpha-MSH [D12.644.548.691.525.690.179]
        
        beta-Endorphin [D12.644.548.691.525.690.239]
        
        beta-Lipotropin [D12.644.548.691.525.690.480]
        
        Corticotropin-Like Intermediate Lobe Peptide [D12.644.548.691.525.690.498]
        
        gamma-Endorphin [D12.644.548.691.525.690.505]
        
        gamma-Lipotropin [D12.644.548.691.525.690.518]
        
        gamma-MSH [D12.644.548.691.525.690.524]
        
        Melanocortins [D12.644.548.691.525.690.531]
        
        Thyrotropin [D12.644.548.691.525.883]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Nerve Tissue Proteins [D12.776.631]
    - Neuropeptides [D12.776.631.650]
      - Hypothalamic Hormones [D12.776.631.650.405]
        
        Pituitary Hormone Release Inhibiting Hormones [D12.776.631.650.405.700]
        
        Pituitary Hormone-Releasing Hormones [D12.776.631.650.405.740]
        
        Pro-Opiomelanocortin [D12.776.631.650.405.935]
        
        alpha-Endorphin [D12.776.631.650.405.935.119]
        
        alpha-MSH [D12.776.631.650.405.935.179]
        
        beta-Endorphin [D12.776.631.650.405.935.239]
        
        beta-Lipotropin [D12.776.631.650.405.935.480]
        
        Corticotropin-Like Intermediate Lobe Peptide [D12.776.631.650.405.935.498]
        
        gamma-Endorphin [D12.776.631.650.405.935.505]
        
        gamma-Lipotropin [D12.776.631.650.405.935.518]
        
        gamma-MSH [D12.776.631.650.405.935.524]
        
        Melanocortins [D12.776.631.650.405.935.531]
        
        Prolactin-Releasing Hormone [D12.776.631.650.405.967]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Protein Precursors [D12.776.811]

Pro-Opiomelanocortin Preferred

Preproopiomelanocortin Narrower

Opiocortin Narrower

Pro-Opiomelanocortin MeSH Descriptor Data 2024