MeSH Browser

MeSH Heading: T-Lymphoma Invasion and Metastasis-inducing Protein 1
Tree Number(s): D12.644.360.325.300.850; D12.776.476.325.300.850
Unique ID: D000075684
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000075684
Scope Note: A Rho guanine nucleotide exchange factor that consists of two pleckstrin homology domains flanking central Ras-binding, Dbl-homology (DH) and PDZ domains. It stimulates GTP-GDP exchange of rho-like GTPases such as RAC1 PROTEIN; CDC42 PROTEIN; and RHOA PROTEIN, and functions to link extracellular signals to remodeling of the CYTOSKELETON for CELL ADHESION and CELL MOVEMENT.
Entry Term(s): TIAM-1 Protein; TIAM1 Protein
Registry Number: 0
Previous Indexing: Guanine Nucleotide Exchange Factors (2007-2017)
See Also: PDZ Domains; Pleckstrin Homology Domains
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000631113
Registry Number: 0
Scope Note: A Rho guanine nucleotide exchange factor that consists of two pleckstrin homology domains flanking central Ras-binding, Dbl-homology (DH) and PDZ domains. It stimulates GTP-GDP exchange of rho-like GTPases such as RAC1 PROTEIN; CDC42 PROTEIN; and RHOA PROTEIN, and functions to link extracellular signals to remodeling of the CYTOSKELETON for CELL ADHESION and CELL MOVEMENT.
Terms: T-Lymphoma Invasion and Metastasis-inducing Protein 1 Preferred Term
Term UI T000923443
Date05/05/2017
LexicalTag NON
ThesaurusID NLM (2018); TIAM-1 Protein
Term UI T000923445
Date05/05/2017
LexicalTag ACX
ThesaurusID NLM (2018); TIAM1 Protein
Term UI T000923444
Date05/05/2017
LexicalTag ACX
ThesaurusID NLM (2018)

T-Lymphoma Invasion and Metastasis-inducing Protein 1 MeSH Descriptor Data 2024