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Cilastatin, Imipenem Drug Combination MeSH Descriptor Data 2022


MeSH Heading
Cilastatin, Imipenem Drug Combination
Tree Number(s)
D02.065.589.099.124.300.500.500
D02.455.426.392.368.533.200.500
D03.633.100.300.124.300.500.500
D10.251.355.325.200.500
D26.310.356
Unique ID
D000077728
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000077728
Scope Note
Combination of imipenem and cilastatin that is used in the treatment of bacterial infections; cilastatin inhibits renal dehydropeptidase I to prolong the half-life and increase the tissue penetration of imipenem, enhancing its efficacy as an anti-bacterial agent.
Entry Term(s)
Imipenem - Cilastatin
Imipenem - Cilastatin Sodium
Imipenem Cilastatin
Imipenem Cilastatin Sodium
Imipenem-Cilastatin
Imipenem-Cilastatin Sodium
Imipenem-Cilastatin, Sodium Salt
MK 0787-MK 0791 mixture
MK 787-MK 791 mixture
Primaxin
Thienam
Tienam 500
Zienam
Pharm Action
Anti-Bacterial Agents
Protease Inhibitors
Registry Number
92309-29-0
Related Numbers
85960-17-4
Public MeSH Note
2019; CILASTATIN, IMIPENEM DRUG COMBINATION was indexed under CILASTATIN and IMIPENEM 1995-2018 and 1988-1994; under DRUG COMBINATIONS 1995-2018 and 1985-1994; and under CYCLOPROPANES and THIENAMYCINS 1985-1988
History Note
2019 (1985)
Date Established
2019/01/01
Date of Entry
2018/07/09
Revision Date
2018/04/10
Cilastatin, Imipenem Drug Combination Preferred
Thienam Narrower
Tienam 500 Narrower
Primaxin Narrower
MK 0787-MK 0791 mixture Narrower
Zienam Narrower
Imipenem-Cilastatin, Sodium Salt Narrower
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