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Dactinomycin MeSH Descriptor Data 2022


MeSH Heading
Dactinomycin
Tree Number(s)
D03.633.300.200
D04.345.566.252
D12.644.641.252
Unique ID
D003609
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D003609
Scope Note
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
Entry Term(s)
Actinomycin
Actinomycin D
Cosmegen
Cosmegen Lyovac
Lyovac-Cosmegen
Meractinomycin
Pharm Action
Anti-Bacterial Agents
Antibiotics, Antineoplastic
Protein Synthesis Inhibitors
Nucleic Acid Synthesis Inhibitors
Registry Number
1CC1JFE158
Related Numbers
50-76-0
CAS Type 1 Name
Actinomycin D
Public MeSH Note
66; ACTINOMYCIN was heading 1963-95
History Note
66; ACTINOMYCIN was heading 1963-95
Date Established
1966/01/01
Date of Entry
1999/01/01
Revision Date
2017/05/24
Dactinomycin Preferred
Actinomycin Broader
Cosmegen Narrower
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