MeSH Browser

MeSH Heading: Colforsin
Tree Number(s): D02.455.849.291.300
Unique ID: D005576
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D005576
Scope Note: Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.
Entry Term(s): Coleonol; Forskolin; N,N-Dimethyl-beta-alanine-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho(2,1-b)pyran-6-yl Ester HCl; NKH 477; NKH-477; NKH477
Pharm Action: Adjuvants, Immunologic
Bronchodilator Agents
Cardiotonic Agents
Vasodilator Agents
Registry Numbers: 1F7A44V6OU; 0
Related Numbers: 138605-00-2; 66428-89-5
CAS Type 1 Name: 1H-Naphtho(2,1-b)pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-
Previous Indexing: Diterpenes (1974-1985); Terpenes (1966-1973)
Public MeSH Note: 2014; see FORSKOLIN 1986-2013
History Note: 2014(1986)
Date Established: 1986/01/01
Date of Entry: 1985/03/08
Revision Date: 2015/06/17

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0358301
Registry Numbers: 1F7A44V6OU
Related Numbers: 138605-00-2; 66428-89-5
Scope Note: Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.
Terms: Colforsin Preferred Term
Term UI T837025
Date02/06/2013
LexicalTag NON
ThesaurusID; Coleonol
Term UI T016909
Date03/08/1985
LexicalTag NON
ThesaurusID UNK (19XX); Forskolin
Term UI T016910
Date01/01/1999
LexicalTag NON
ThesaurusID; N,N-Dimethyl-beta-alanine-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho(2,1-b)pyran-6-yl Ester HCl
Term UI T837854
Date02/26/2013
LexicalTag NON
ThesaurusID NLM (2014)

Colforsin MeSH Descriptor Data 2024