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Aphidicolin MeSH Descriptor Data 2023


MeSH Heading
Aphidicolin
Tree Number(s)
D02.455.849.291.075
Unique ID
D016590
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D016590
Scope Note
An antiviral antibiotic produced by Cephalosporium aphidicola and other fungi. It inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.
Entry Term(s)
Aphidicolin, (3-S-(3alpha,4beta,4abeta,6aalpha,8alpha,9alpha,11aalpha,11balpha))-Isomer
ICI-69653
NSC-234714
NSC-351140
Pharm Action
Antiviral Agents
Enzyme Inhibitors
Registry Number
38966-21-1
Related Numbers
52645-92-8
CAS Type 1 Name
9,15-Cyclo-C,18-dinor-14,15-secoandrostane-4,17-dimethanol, 3,17-dihydroxy-4-methyl-, (3alpha,4alpha,5alpha,17alpha)-
Previous Indexing
Antiviral Agents (1966-1991)
DNA Polymerases/antagonists & inhibitors (1977-1991)
Diterpenes (1974-1991)
Public MeSH Note
92; APHIDICOLIN was indexed under DITERPENES 1974-91
Online Note
use APHIDICOLIN (NM) to search APHIDICOLIN 1980-91
History Note
92; was APHIDICOLIN (NM) 1974-91
Date Established
1992/01/01
Date of Entry
1991/01/24
Revision Date
2000/06/21
Aphidicolin Preferred
NSC-351140 Narrower
NSC-234714 Narrower
Aphidicolin, (3-S-(3alpha,4beta,4abeta,6aalpha,8alpha,9alpha,11aalpha,11balpha))-Isomer Related
ICI-69653 Narrower
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