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Purpura, Thrombotic Thrombocytopenic MeSH Descriptor Data 2025


MeSH Heading
Purpura, Thrombotic Thrombocytopenic
Tree Number(s)
C15.378.100.802.687.680
C15.378.140.855.925.750.680
C15.378.243.937.925.750.680
C15.378.925.850
C23.550.414.950.687.680
C23.888.885.687.687.680
Unique ID
D011697
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D011697
Scope Note
An acquired, congenital, or familial disorder caused by PLATELET AGGREGATION with THROMBOSIS in terminal arterioles and capillaries. Clinical features include THROMBOCYTOPENIA; HEMOLYTIC ANEMIA; AZOTEMIA; FEVER; and thrombotic microangiopathy. The classical form also includes neurological symptoms and end-organ damage, such as RENAL FAILURE. Mutations in the ADAMTS13 PROTEIN gene have been identified in familial cases.
Entry Term(s)
Congenital Thrombotic Thrombocytopenic Purpura
Familial Thrombotic Thrombocytopenia Purpura
Familial Thrombotic Thrombocytopenic Purpura
Microangiopathic Hemolytic Anemia, Congenital
Moschcowitz Disease
Moschkowitz Disease
Purpura, Thrombotic Thrombopenic
Schulman-Upshaw Syndrome
Thrombotic Microangiopathy, Familial
Thrombotic Thrombocytopenic Purpura
Thrombotic Thrombocytopenic Purpura, Congenital
Thrombotic Thrombocytopenic Purpura, Familial
Upshaw Factor, Deficiency of
Upshaw-Schulman Syndrome
Public MeSH Note
1986; see PURPURA, THROMBOTIC THROMBOPENIC 1965-1985
History Note
1986; use PURPURA, THROMBOTIC THROMBOPENIC 1965-1985
Date Established
1965/01/01
Date of Entry
1999/01/01
Revision Date
2023/02/26
Purpura, Thrombotic Thrombocytopenic Preferred
Congenital Thrombotic Thrombocytopenic Purpura Narrower
Familial Thrombotic Thrombocytopenic Purpura Narrower
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