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Protein S Deficiency MeSH Descriptor Data 2025


MeSH Heading
Protein S Deficiency
Tree Number(s)
C15.378.100.800
C15.378.147.890
C15.378.925.800
Unique ID
D018455
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D018455
Scope Note
An autosomal dominant disorder showing decreased levels of plasma protein S antigen or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein C deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (From Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology, 9th ed, p1523)
Entry Version
PROTEIN S DEFIC
Entry Term(s)
Deficiency, Protein S
Hereditary Thrombophilia Due To Protein S Deficiency
Previous Indexing
Glycoproteins/deficiency (1984-1992)
Protein S/deficiency (1993-1994)
Public MeSH Note
95
History Note
95
Date Established
1995/01/01
Date of Entry
1994/04/16
Revision Date
2013/07/08
Protein S Deficiency Preferred
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