MeSH Browser

MeSH Heading: Multiple Endocrine Neoplasia Type 2a
Tree Number(s): C04.588.322.400.505; C04.651.600.505; C04.700.630.505; C16.320.700.630.505; C19.344.400.505
Unique ID: D018813
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D018813
Annotation: coordinate IM with specific endocrine/neoplasm pre-coordinates (IM) + specific histological type (IM) if pertinent
Scope Note: A form of multiple endocrine neoplasia characterized by the presence of medullary carcinoma (CARCINOMA, MEDULLARY) of the THYROID GLAND, and usually with the co-occurrence of PHEOCHROMOCYTOMA, producing CALCITONIN and ADRENALINE, respectively. Less frequently, it can occur with hyperplasia or adenoma of the PARATHYROID GLANDS. This disease is due to gain-of-function mutations of the MEN2 gene on CHROMOSOME 10 (Locus: 10q11.2), also known as the RET proto-oncogene that encodes a RECEPTOR PROTEIN-TYROSINE KINASE. It is an autosomal dominant inherited disease.
Entry Version: MULTIPLE ENDOCRINE NEOPL TYPE 2A
Entry Term(s): MEA 2a; MEA II; MEA IIa; MEN 2; MEN 2a; MEN II; MEN IIa; MEN-2A Syndrome; MEN2a; Multiple Endocrine Neoplasia Type 2; Multiple Endocrine Neoplasia, Type IIa; Multiple Endocrine Neoplasms Type 2a; Neoplasia, Multiple Endocrine Type 2a; Neoplasms, Multiple Endocrine Type 2a; Pheochromocytoma And Amyloid-Producing Medullary Thyroid Carcinoma; Sipple Syndrome
Previous Indexing: Multiple Endocrine Neoplasia (1966-1994)
Public MeSH Note: 95; MEA II, MEN II, & SIPPLE SYNDROME were see NEOPLASMS, MULTIPLE ENDOCRINE 1983-94
Online Note: use MULTIPLE ENDOCRINE NEOPLASIA to search MEA II, MEN II, & SIPPLE SYNDROME 1983-94
History Note: 95; MEA II, MEN II, & SIPPLE SYNDROME were see NEOPLASMS, MULTIPLE ENDOCRINE 1983-94
Date Established: 1995/01/01
Date of Entry: 1994/05/23
Revision Date: 2012/07/03

Allowable Qualifiers: blood (BL)

blood supply (BS)

cerebrospinal fluid (CF)

chemically induced (CI)

chemistry (CH)

classification (CL)

complications (CO)

congenital (CN)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

secondary (SC)

surgery (SU)

therapy (TH)

ultrastructure (UL)

urine (UR)

veterinary (VE)

virology (VI)

Neoplasms [C04]
- Neoplasms by Site [C04.588]
  - Endocrine Gland Neoplasms [C04.588.322]
    - Multiple Endocrine Neoplasia [C04.588.322.400]

Neoplasms [C04]
- Neoplasms, Multiple Primary [C04.651]
  - Multiple Endocrine Neoplasia [C04.651.600]

Neoplasms [C04]
- Neoplastic Syndromes, Hereditary [C04.700]
  - Multiple Endocrine Neoplasia [C04.700.630]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Neoplastic Syndromes, Hereditary [C16.320.700]
    - Multiple Endocrine Neoplasia [C16.320.700.630]

Endocrine System Diseases [C19]
- Endocrine Gland Neoplasms [C19.344]
  - Multiple Endocrine Neoplasia [C19.344.400]

Multiple Endocrine Neoplasia Type 2a Preferred

Concept UI: M0028166
Scope Note: A form of multiple endocrine neoplasia characterized by the presence of medullary carcinoma (CARCINOMA, MEDULLARY) of the THYROID GLAND, and usually with the co-occurrence of PHEOCHROMOCYTOMA, producing CALCITONIN and ADRENALINE, respectively. Less frequently, it can occur with hyperplasia or adenoma of the PARATHYROID GLANDS. This disease is due to gain-of-function mutations of the MEN2 gene on CHROMOSOME 10 (Locus: 10q11.2), also known as the RET proto-oncogene that encodes a RECEPTOR PROTEIN-TYROSINE KINASE. It is an autosomal dominant inherited disease.
Terms: Multiple Endocrine Neoplasia Type 2a Preferred Term
Term UI T056057
Date01/01/1999
LexicalTag NON
ThesaurusID; MEA 2a
Term UI T056061
Date04/01/1994
LexicalTag ABB
ThesaurusID NLM (1995); MEA II
Term UI T056052
Date04/01/1994
LexicalTag ABB
ThesaurusID NLM (1995); Pheochromocytoma And Amyloid-Producing Medullary Thyroid Carcinoma
Term UI T811745
Date11/15/2011
LexicalTag NON
ThesaurusID OMIM (2013); Sipple Syndrome
Term UI T056054
Date04/01/1994
LexicalTag EPO
ThesaurusID; Multiple Endocrine Neoplasia, Type IIa
Term UI T825067
Date06/27/2012
LexicalTag NON
ThesaurusID OMIM (2013); MEA IIa
Term UI T056063
Date04/01/1994
LexicalTag ABB
ThesaurusID NLM (1995); MEN 2
Term UI T056055
Date04/01/1994
LexicalTag ABB
ThesaurusID NLM (1995); MEN 2a
Term UI T056060
Date04/01/1994
LexicalTag ABB
ThesaurusID; MEN II
Term UI T056053
Date04/01/1994
LexicalTag ABB
ThesaurusID NLM (1995); MEN IIa
Term UI T056062
Date04/01/1994
LexicalTag ABB
ThesaurusID NLM (1995); MEN-2A Syndrome
Term UI T767839
Date03/24/2010
LexicalTag ABX
ThesaurusID; MEN2a
Term UI T056064
Date04/01/1994
LexicalTag ABB
ThesaurusID; Multiple Endocrine Neoplasia Type 2
Term UI T603140
Date08/13/2004
LexicalTag NON
ThesaurusID NLM (2006); Multiple Endocrine Neoplasms Type 2a
Term UI T056058
Date04/01/1994
LexicalTag NON
ThesaurusID NLM (1995); Neoplasia, Multiple Endocrine Type 2a
Term UI T056056
Date04/01/1994
LexicalTag NON
ThesaurusID NLM (1995); Neoplasms, Multiple Endocrine Type 2a
Term UI T056059
Date04/01/1994
LexicalTag NON
ThesaurusID NLM (1995)

Multiple Endocrine Neoplasia Type 2a MeSH Descriptor Data 2024