NLM Logo

Multiple Endocrine Neoplasia Type 2a MeSH Descriptor Data 2024


MeSH Heading
Multiple Endocrine Neoplasia Type 2a
Tree Number(s)
C04.588.322.400.505
C04.651.600.505
C04.700.630.505
C16.320.700.630.505
C19.344.400.505
Unique ID
D018813
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D018813
Annotation
coordinate IM with specific endocrine/neoplasm pre-coordinates (IM) + specific histological type (IM) if pertinent
Scope Note
A form of multiple endocrine neoplasia characterized by the presence of medullary carcinoma (CARCINOMA, MEDULLARY) of the THYROID GLAND, and usually with the co-occurrence of PHEOCHROMOCYTOMA, producing CALCITONIN and ADRENALINE, respectively. Less frequently, it can occur with hyperplasia or adenoma of the PARATHYROID GLANDS. This disease is due to gain-of-function mutations of the MEN2 gene on CHROMOSOME 10 (Locus: 10q11.2), also known as the RET proto-oncogene that encodes a RECEPTOR PROTEIN-TYROSINE KINASE. It is an autosomal dominant inherited disease.
Entry Version
MULTIPLE ENDOCRINE NEOPL TYPE 2A
Entry Term(s)
MEA 2a
MEA II
MEA IIa
MEN 2
MEN 2a
MEN II
MEN IIa
MEN-2A Syndrome
MEN2a
Multiple Endocrine Neoplasia Type 2
Multiple Endocrine Neoplasia, Type IIa
Multiple Endocrine Neoplasms Type 2a
Neoplasia, Multiple Endocrine Type 2a
Neoplasms, Multiple Endocrine Type 2a
Pheochromocytoma And Amyloid-Producing Medullary Thyroid Carcinoma
Sipple Syndrome
Previous Indexing
Multiple Endocrine Neoplasia (1966-1994)
Public MeSH Note
95; MEA II, MEN II, & SIPPLE SYNDROME were see NEOPLASMS, MULTIPLE ENDOCRINE 1983-94
Online Note
use MULTIPLE ENDOCRINE NEOPLASIA to search MEA II, MEN II, & SIPPLE SYNDROME 1983-94
History Note
95; MEA II, MEN II, & SIPPLE SYNDROME were see NEOPLASMS, MULTIPLE ENDOCRINE 1983-94
Date Established
1995/01/01
Date of Entry
1994/05/23
Revision Date
2012/07/03
Multiple Endocrine Neoplasia Type 2a Preferred
page delivered in 0.159s