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Immunophilins MeSH Descriptor Data 2022


MeSH Heading
Immunophilins
Tree Number(s)
D08.811.399.325.500.400
D12.776.543.750.705.400
D12.776.827.275
Unique ID
D020104
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D020104
Annotation
don't confuse entry term NEUROPHILINS with NEUROPILINS
Scope Note
Members of a family of highly conserved proteins which are all cis-trans peptidyl-prolyl isomerases (PEPTIDYLPROLYL ISOMERASE). They bind the immunosuppressant drugs CYCLOSPORINE; TACROLIMUS and SIROLIMUS. They possess rotamase activity, which is inhibited by the immunosuppressant drugs that bind to them.
Entry Term(s)
Immunophilin
Neurophilin
Neurophilins
Registry Number
EC 5.2.1.8
Related Numbers
EC 5.2.1.8
Previous Indexing
Immunosuppressive Agents (1990-1998)
Public MeSH Note
2004; NEUROPHILIN was indexed under LYMPHOKINES 1974-2003; ENDOTHELIAL GROWTH FACTORS 1991-2003 & INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS 2002
History Note
2004(1999); for NEUROPHILIN use VASCULAR ENDOTHELIAL GROWTH FACTOR (NM) 1997-2003
Date Established
1999/01/01
Date of Entry
1998/06/10
Revision Date
2020/05/27
Immunophilins Preferred
Neurophilins Related
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