MeSH Browser

MeSH Heading: B7-2 Antigen
Tree Number(s): D12.776.465.500; D12.776.467.150.200; D12.776.543.095.200; D23.050.301.285.200; D23.529.168.200
Unique ID: D051940
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D051940
Scope Note: A costimulatory ligand glycoprotein that contains a C2 and V-type IMMUNOGLOBULIN DOMAIN. It is expressed by ANTIGEN-PRESENTING CELLS and binds to CD28 ANTIGEN with high specificity and to CTLA-4 ANTIGEN with low specificity. The interaction of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Entry Term(s): Antigen, B7-2; Antigens, CD86; B7-2 Costimulatory Molecule; B70 Costimulatory Molecule; CD86 Antigen; CD86 Antigens; Early T Cell Costimulatory Molecule 1
Registry Numbers: 0
See Also: Immunoglobulin Domains
Public MeSH Note: 2018; see ANTIGENS, CD86 2006-2017; B7-2 ANTIGEN was indexed under MEMBRANE GLYCOPROTEINS and ANTIGENS, CD 1996-2005; and under B-CELL ACTIVATION ANTIGEN 1993-1995
History Note: 2018 (1993)
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2020/03/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0223248
Registry Numbers: 0
Scope Note: A costimulatory ligand glycoprotein that contains a C2 and V-type IMMUNOGLOBULIN DOMAIN. It is expressed by ANTIGEN-PRESENTING CELLS and binds to CD28 ANTIGEN with high specificity and to CTLA-4 ANTIGEN with low specificity. The interaction of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Terms: B7-2 Antigen Preferred Term
Term UI T636315
Date04/12/2005
LexicalTag ABX
ThesaurusID NLM (2006); Early T Cell Costimulatory Molecule 1
Term UI T253252
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); Antigens, CD86
Term UI T633987
Date03/22/2005
LexicalTag ABX
ThesaurusID NLM (2006); CD86 Antigens
Term UI T636293
Date04/12/2005
LexicalTag ABX
ThesaurusID NLM (2006); Antigen, B7-2
Term UI T636314
Date04/12/2005
LexicalTag ABX
ThesaurusID NLM (2006); B7-2 Costimulatory Molecule
Term UI T253247
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2006); CD86 Antigen
Term UI T253250
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2006); B70 Costimulatory Molecule
Term UI T253249
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2006)

B7-2 Antigen MeSH Descriptor Data 2025