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B7-2 Antigen MeSH Descriptor Data 2022


MeSH Heading
B7-2 Antigen
Tree Number(s)
D12.776.465.500
D12.776.467.150.200
D12.776.543.095.200
D23.050.301.285.200
D23.529.168.200
Unique ID
D051940
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D051940
Scope Note
A costimulatory ligand glycoprotein that contains a C2 and V-type IMMUNOGLOBULIN DOMAIN. It is expressed by ANTIGEN-PRESENTING CELLS and binds to CD28 ANTIGEN with high specificity and to CTLA-4 ANTIGEN with low specificity. The interaction of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Entry Term(s)
Antigen, B7-2
Antigens, CD86
B7-2 Costimulatory Molecule
B70 Costimulatory Molecule
CD86 Antigen
CD86 Antigens
Early T Cell Costimulatory Molecule 1
Registry Number
0
See Also
Immunoglobulin Domains
Public MeSH Note
2018; see ANTIGENS, CD86 2006-2017; B7-2 ANTIGEN was indexed under MEMBRANE GLYCOPROTEINS and ANTIGENS, CD 1996-2005; and under B-CELL ACTIVATION ANTIGEN 1993-1995
History Note
2018 (1993)
Date Established
2006/01/01
Date of Entry
2005/06/30
Revision Date
2020/03/27
B7-2 Antigen Preferred
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