MeSH Browser

MeSH Heading: TYK2 Kinase
Tree Number(s): D08.811.913.696.620.682.725.124.650; D12.776.476.568.124.650
Unique ID: D053634
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D053634
Scope Note: A Janus kinase subtype that is involved in signaling from a broad variety of CYTOKINE RECEPTORS. The TYK2 kinase is considered the founding member of the janus kinase family and was initially discovered as a signaling partner for the INTERFERON ALPHA-BETA RECEPTOR. The kinase has since been shown to signal from several INTERLEUKIN RECEPTORS.
Entry Term(s): Non-Receptor Tyrosine-Protein Kinase TYK2; Tyrosine Kinase 2
Registry Numbers: EC 2.7.10.2
Previous Indexing: Protein-Tyrosine Kinase (1991-2006)
See Also: src Homology Domains
Public MeSH Note: 2007
History Note: 2007
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0495106
Registry Numbers: EC 2.7.10.2
Scope Note: A Janus kinase subtype that is involved in signaling from a broad variety of CYTOKINE RECEPTORS. The TYK2 kinase is considered the founding member of the janus kinase family and was initially discovered as a signaling partner for the INTERFERON ALPHA-BETA RECEPTOR. The kinase has since been shown to signal from several INTERLEUKIN RECEPTORS.
Terms: TYK2 Kinase Preferred Term
Term UI T666612
Date02/17/2006
LexicalTag ABX
ThesaurusID NLM (2007); Tyrosine Kinase 2
Term UI T666613
Date02/17/2006
LexicalTag NON
ThesaurusID NLM (2007); Non-Receptor Tyrosine-Protein Kinase TYK2
Term UI T666614
Date02/17/2006
LexicalTag ABX
ThesaurusID NLM (2007)

TYK2 Kinase MeSH Descriptor Data 2025