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A family of crosslinking filament proteins encoded by distinct FLN genes. Filamins are involved in cell adhesion, spreading, and migration, acting as scaffolds for over 90 binding partners including channels, receptors, intracellular signaling molecules and transcription factors. Due to the range of molecular interactions, mutations in FLN genes result in anomalies with moderate to lethal consequences.
Entry Term(s)
280 kDa Actin-Binding Protein
Filamin
Filamin 1
Filamin 1-Like Protein
Filamin A
Filamin B
Filamin C
Merofilamins
alpha-Filamin
beta-Filamin
Registry Numbers
0
Public MeSH Note
2014; was indexed under CONTRACTILE PROTEINS and MICROFILAMENT PROTEINS 1977-2013.
A family of crosslinking filament proteins encoded by distinct FLN genes. Filamins are involved in cell adhesion, spreading, and migration, acting as scaffolds for over 90 binding partners including channels, receptors, intracellular signaling molecules and transcription factors. Due to the range of molecular interactions, mutations in FLN genes result in anomalies with moderate to lethal consequences.