MeSH Browser

MeSH Heading: Agammaglobulinaemia Tyrosine Kinase
Tree Number(s): D08.811.913.696.620.682.725.025; D12.776.476.568.025
Unique ID: D000077329
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000077329
Scope Note: A non-receptor tyrosine kinase that is essential for the development, maturation, and signaling of B-LYMPHOCYTES. It contains an N-terminal zinc finger motif and localizes primarily to the PLASMA MEMBRANE and nucleus of B-lymphocytes. Mutations in the gene that encode this kinase are associated with X-LINKED AGAMMAGLOBULINEMIA.
Entry Term(s): B Cell Progenitor Kinase; Bruton's Tyrosine Kinase
Registry Numbers: EC 2.7.10.2
Public MeSH Note: 2019; AGAMMAGLOBULINAEMIA TYROSINE KINASE was indexed under PROTEIN-TYROSINE KINASES 1993-2018
History Note: 2019 (1993)
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2021/05/20

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0219038
Registry Numbers: EC 2.7.10.2
Scope Note: A non-receptor tyrosine kinase that is essential for the development, maturation, and signaling of B-LYMPHOCYTES. It contains an N-terminal zinc finger motif and localizes primarily to the PLASMA MEMBRANE and nucleus of B-lymphocytes. Mutations in the gene that encode this kinase are associated with X-LINKED AGAMMAGLOBULINEMIA.
Terms: Agammaglobulinaemia Tyrosine Kinase Preferred Term
Term UI T000939267
Date01/17/2018
LexicalTag NON
ThesaurusID NLM (2004); B Cell Progenitor Kinase
Term UI T000939268
Date01/17/2018
LexicalTag NON
ThesaurusID NLM (2004); Bruton's Tyrosine Kinase
Term UI T000939269
Date01/17/2018
LexicalTag NON
ThesaurusID NLM (1993)

Agammaglobulinaemia Tyrosine Kinase MeSH Descriptor Data 2024