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Agammaglobulinaemia Tyrosine Kinase MeSH Descriptor Data 2025
A non-receptor tyrosine kinase that is essential for the development, maturation, and signaling of B-LYMPHOCYTES. It contains an N-terminal zinc finger motif and localizes primarily to the PLASMA MEMBRANE and nucleus of B-lymphocytes. Mutations in the gene that encode this kinase are associated with X-LINKED AGAMMAGLOBULINEMIA.
Entry Term(s)
B Cell Progenitor Kinase
Bruton's Tyrosine Kinase
Registry Numbers
EC 2.7.10.2
Public MeSH Note
2019; AGAMMAGLOBULINAEMIA TYROSINE KINASE was indexed under PROTEIN-TYROSINE KINASES 1993-2018
A non-receptor tyrosine kinase that is essential for the development, maturation, and signaling of B-LYMPHOCYTES. It contains an N-terminal zinc finger motif and localizes primarily to the PLASMA MEMBRANE and nucleus of B-lymphocytes. Mutations in the gene that encode this kinase are associated with X-LINKED AGAMMAGLOBULINEMIA.