MeSH Browser

MeSH Heading: CLOCK Proteins
Tree Number(s): D08.811.913.050.134.415.500.049; D12.644.360.138.100; D12.776.260.103.562; D12.776.476.156.200; D12.776.930.125.562
Unique ID: D056926
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D056926
Scope Note: Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.
Entry Term(s): CLOCK Protein; Circadian Locomotor Output Cycles Kaput Proteins
Registry Numbers: EC 2.3.1.48
Public MeSH Note: 2010; CLOCK PROTEIN (now CLOCK PROTEINS) was indexed under TRANSACTIVATORS 1997-2009
History Note: 2010(1997)
Date Established: 2010/01/01
Date of Entry: 2009/07/06
Revision Date: 2018/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0533475
Registry Numbers: EC 2.3.1.48
Scope Note: Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.
Terms: CLOCK Proteins Preferred Term
Term UI T747415
Date03/11/2009
LexicalTag ACX
ThesaurusID NLM (2010); CLOCK Protein
Term UI T747416
Date03/11/2009
LexicalTag ACX
ThesaurusID NLM (2010); Circadian Locomotor Output Cycles Kaput Proteins
Term UI T755383
Date07/27/2009
LexicalTag NON
ThesaurusID NLM (2010)

CLOCK Proteins MeSH Descriptor Data 2024