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Factor XII MeSH Descriptor Data 2025


MeSH Heading
Factor XII
Tree Number(s)
D08.622.500
D12.776.124.125.450
D12.776.811.243.500
D23.119.450
Unique ID
D005174
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D005174
Scope Note
Stable blood coagulation factor activated by contact with the subendothelial surface of an injured vessel. Along with prekallikrein, it serves as the contact factor that initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased incidence of thromboembolic disease. Mutations in the gene for factor XII that appear to increase factor XII amidolytic activity are associated with HEREDITARY ANGIOEDEMA TYPE III.
Entry Term(s)
Coagulation Factor XII
Factor 12
Factor Twelve
Hageman Factor
Registry Numbers
9001-30-3
CAS Type 1 Name
Blood-coagulation factor XII
See Also
Coagulants
Hereditary Angioedema Type III
Public MeSH Note
66
History Note
66(64)
Entry Combination
deficiency:Factor XII Deficiency
Date Established
1966/01/01
Date of Entry
1999/01/01
Revision Date
2019/05/30
Factor XII Preferred
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