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Integrins MeSH Descriptor Data 2022


MeSH Heading
Integrins
Tree Number(s)
D12.776.543.750.705.408
Unique ID
D016023
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D016023
Annotation
prefer specifics
Scope Note
A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors (RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.
Entry Term(s)
Integrin
Registry Number
0
Previous Indexing
Glycoproteins (1966-1987)
Membrane Glycoproteins (1988-1989)
Receptors, Endogenous Substances (1973-1989)
Receptors, Immunologic (1980-1989)
See Also
Cell Adhesion Molecules
Public MeSH Note
90
History Note
90
Date Established
1990/01/01
Date of Entry
1989/07/07
Revision Date
2021/06/30
Integrins Preferred
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