MeSH Browser

MeSH Heading: Procollagen N-Endopeptidase
Tree Number(s): D08.811.277.656.300.480.664; D08.811.277.656.675.374.664
Unique ID: D011348
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D011348
Scope Note: An extracellular endopeptidase which excises a block of peptides at the amino terminal, nonhelical region of the procollagen molecule with the formation of collagen. Absence or deficiency of the enzyme causes accumulation of procollagen which results in the inherited connective tissue disorder--dermatosparaxis. EC 3.4.24.14.
Entry Term(s): Procollagen N-Proteinase; Procollagen Peptidase
Registry Numbers: EC 3.4.24.14
Previous Indexing: Collagen (1966-1976); Peptide Peptidohydrolases (1966-1976); Protein Precursors (1973-1976)
Public MeSH Note: 97; was PROCOLLAGEN PEPTIDASE 1977-96 (see under PEPTIDE PEPTIDOHYDROLASES 1977-90)
History Note: 97; was PROCOLLAGEN PEPTIDASE 1977-96 (see under ENDOPEPTIDASES 1977-90)
Date Established: 1991/01/01
Date of Entry: 1976/04/27
Revision Date: 2003/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0017631
Registry Numbers: EC 3.4.24.14
Scope Note: An extracellular endopeptidase which excises a block of peptides at the amino terminal, nonhelical region of the procollagen molecule with the formation of collagen. Absence or deficiency of the enzyme causes accumulation of procollagen which results in the inherited connective tissue disorder--dermatosparaxis. EC 3.4.24.14.
Terms: Procollagen N-Endopeptidase Preferred Term
Term UI T033473
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1977); Procollagen N-Proteinase
Term UI T033471
Date02/08/1989
LexicalTag NON
ThesaurusID NLM (1989); Procollagen Peptidase
Term UI T033472
Date12/12/1995
LexicalTag NON
ThesaurusID NLM (1997)

Procollagen N-Endopeptidase MeSH Descriptor Data 2025