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Pregnancy-Associated Plasma Protein-A MeSH Descriptor Data 2023


MeSH Heading
Pregnancy-Associated Plasma Protein-A
Tree Number(s)
D08.811.277.656.300.480.632
D08.811.277.656.675.374.632
D12.776.780.700
Unique ID
D011266
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D011266
Scope Note
A product of the PLACENTA, and DECIDUA, secreted into the maternal circulation during PREGNANCY. It has been identified as an IGF binding protein (IGFBP)-4 protease that proteolyzes IGFBP-4 and thus increases IGF bioavailability. It is found also in human FIBROBLASTS, ovarian FOLLICULAR FLUID, and GRANULOSA CELLS. The enzyme is a heterotetramer of about 500-kDa.
Entry Version
PREGN ASSOCIATED PLASMA PROTEIN A
Entry Term(s)
IGFBP-4 Metalloproteinase
IGFBP-4 Protease
IGFBP-4-Specific Proteinase
Insulin-Like Growth Factor-Dependent IGF Binding Protein-4 Protease
Insulin-Like-Growth Factor Binding Protein-4 Protease
PAPP-A
PAPP-alpha
Pregnancy Associated alpha Plasma Protein
Pregnancy-Associated alpha-Plasma Protein
Registry Number
EC 3.4.24.-
Previous Indexing
Alpha Globulins (1966-1979)
Alpha Macroglobulins (1976-1979)
Blood Proteins (1966-1979)
Glycoproteins (1966-1979)
Pregnancy (1966-1979)
Public MeSH Note
2004; for PREGNANCY-ASSOCIATED ALPHA-PLASMA PROTEIN see PREGNANCY-ASSOCIATED ALPHA-PLASMA PROTEIN 1991-2003, see PREGNANCY PROTEINS 1980-1990
History Note
2004 (1996)
Date Established
1991/01/01
Date of Entry
1979/02/22
Revision Date
2004/07/13
Pregnancy-Associated Plasma Protein-A Preferred
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