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Endothelin-Converting Enzymes MeSH Descriptor Data 2025
2017; ENDOTHELIN CONVERTING ENZYMES was indexed under METALLOENDOPEPTIDASES and ASPARTIC ACID ENDOPEPTIDASES 1991-2016; and under PEPTIDE PEPTIDOHYDROLASES 1990-1991
An integral membrane metalloendodpeptidase which converts BIG ENDOTHELIN to ENDOTHELIN-1 through hydrolysis of the TRYPTOPHAN (21)-VALINE (22) bond . It is also involved in the processing of various neuroendocrine peptides and may have methyltransferase activity.
Converts BIG ENDOTHELIN to ENDOTHELIN-1 through hydrolysis of the TRYPTOPHAN (21)-VALINE (22) bond. Mutations in the endothelin-converting enzyme 1 (ECE1) gene are associated with cases of HIRSCHSPRUNG DISEASE with cardiac defects and autonomic dysfunction.