MeSH Browser

MeSH Heading: Neprilysin
Tree Number(s): D08.811.277.656.300.480.600; D08.811.277.656.675.374.600; D23.050.285.550; D23.101.140.500
Unique ID: D015260
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015260
Scope Note: Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.
Entry Term(s): Antigens, CD10; Antigens, Leukemia, Common Acute Lymphoblastic; Atriopeptidase; CALLA Antigen; CD10 Antigen; CD10 Antigens; Common Acute Lymphoblastic Leukemia Antigens; Endopeptidase-24.11; Enkephalin Dipeptidyl Carboxypeptidase; Enkephalinase; Enkephalinase-24.11; Kidney-Brush-Border Neutral Proteinase; Membrane Metallo-Endopeptidase; Neutral Endopeptidase; Neutral Endopeptidase 24.11; Thermolysin-Like Metalloendopeptidase; YGG-Forming Enzyme
Registry Numbers: EC 3.4.24.11
Previous Indexing: Metalloproteinases (1987-1988); Peptide Peptidohydrolases (1966-1987)
Public MeSH Note: 1997; was MEMBRANE METALLO-ENDOPEPTIDASE 1989-96; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGENS was indexed under ANTIGENS, NEOPLASM & ANTIGENS, DIFFERENTIATION 1983-92; for CALLA ANTIGEN see CALLA 1993-2002
Online Note: use NEPRILYSIN (NM) to search COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGENS 1983-92
History Note: 1997; was MEMBRANE METALLO-ENDOPEPTIDASE 1989-96; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGENS was COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGENS (NM) 1983-92
Date Established: 1989/01/01
Date of Entry: 1988/05/18
Revision Date: 2017/05/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Endopeptidases [D08.811.277.656.300]
        
        Metalloendopeptidases [D08.811.277.656.300.480]
        
        Botulinum Toxins [D08.811.277.656.300.480.153]
        
        Collagenases [D08.811.277.656.300.480.205]
        
        Endothelin-Converting Enzymes [D08.811.277.656.300.480.229]
        
        Gelatinases [D08.811.277.656.300.480.252]
        
        Insulysin [D08.811.277.656.300.480.300]
        
        Lysostaphin [D08.811.277.656.300.480.452]
        
        Matrix Metalloproteinases [D08.811.277.656.300.480.525]
        
        Mitochondrial Processing Peptidase [D08.811.277.656.300.480.563]
        
        Neprilysin [D08.811.277.656.300.480.600]
        
        PHEX Phosphate Regulating Neutral Endopeptidase [D08.811.277.656.300.480.616]
        
        Pregnancy-Associated Plasma Protein-A [D08.811.277.656.300.480.632]
        
        Procollagen N-Endopeptidase [D08.811.277.656.300.480.664]
        
        Pronase [D08.811.277.656.300.480.680]
        
        Thermolysin [D08.811.277.656.300.480.827]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Metalloproteases [D08.811.277.656.675]
        
        Metalloendopeptidases [D08.811.277.656.675.374]
        
        ADAM Proteins [D08.811.277.656.675.374.102]
        
        Botulinum Toxins [D08.811.277.656.675.374.153]
        
        Collagenases [D08.811.277.656.675.374.205]
        
        Endothelin-Converting Enzymes [D08.811.277.656.675.374.229]
        
        Gelatinases [D08.811.277.656.675.374.252]
        
        Insulysin [D08.811.277.656.675.374.300]
        
        Lysostaphin [D08.811.277.656.675.374.452]
        
        Matrix Metalloproteinases [D08.811.277.656.675.374.525]
        
        Mitochondrial Processing Peptidase [D08.811.277.656.675.374.563]
        
        Neprilysin [D08.811.277.656.675.374.600]
        
        PHEX Phosphate Regulating Neutral Endopeptidase [D08.811.277.656.675.374.616]
        
        Pregnancy-Associated Plasma Protein-A [D08.811.277.656.675.374.632]
        
        Procollagen N-Endopeptidase [D08.811.277.656.675.374.664]
        
        Pronase [D08.811.277.656.675.374.680]
        
        Thermolysin [D08.811.277.656.675.374.827]

Biological Factors [D23]
- Antigens [D23.050]
  - Antigens, Neoplasm [D23.050.285]

Biological Factors [D23]
- Biomarkers [D23.101]
  - Biomarkers, Tumor [D23.101.140]

Neprilysin Preferred

Concept UI: M0023500
Registry Numbers: EC 3.4.24.11
Scope Note: Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.
Terms: Neprilysin Preferred Term
Term UI T044821
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1989); Enkephalin Dipeptidyl Carboxypeptidase
Term UI T044805
Date05/18/1988
LexicalTag NON
ThesaurusID UNK (19XX); Enkephalinase
Term UI T044806
Date05/18/1988
LexicalTag NON
ThesaurusID UNK (19XX); Enkephalinase-24.11
Term UI T044807
Date05/18/1988
LexicalTag NON
ThesaurusID UNK (19XX); Kidney-Brush-Border Neutral Proteinase
Term UI T044808
Date05/18/1988
LexicalTag NON
ThesaurusID UNK (19XX); Membrane Metallo-Endopeptidase
Term UI T044809
Date12/12/1995
LexicalTag NON
ThesaurusID NLM (1997); Neutral Endopeptidase
Term UI T044810
Date08/26/1988
LexicalTag NON
ThesaurusID UNK (19XX); Neutral Endopeptidase 24.11
Term UI T044811
Date06/09/1989
LexicalTag NON
ThesaurusID NLM (1990); Thermolysin-Like Metalloendopeptidase
Term UI T044812
Date05/18/1988
LexicalTag NON
ThesaurusID UNK (19XX); YGG-Forming Enzyme
Term UI T044813
Date05/18/1988
LexicalTag NON
ThesaurusID UNK (19XX); Common Acute Lymphoblastic Leukemia Antigens
Term UI T044814
Date03/11/1992
LexicalTag NON
ThesaurusID NLM (1993); Antigens, Leukemia, Common Acute Lymphoblastic
Term UI T044815
Date03/11/1992
LexicalTag NON
ThesaurusID NLM (1993); Atriopeptidase
Term UI T044816
Date01/15/1991
LexicalTag NON
ThesaurusID NLM (1992); CD10 Antigen
Term UI T044818
Date03/18/1992
LexicalTag NON
ThesaurusID NLM (1993); Antigens, CD10
Term UI T044819
Date03/11/1992
LexicalTag NON
ThesaurusID NLM (1993); CD10 Antigens
Term UI T044820
Date03/11/1992
LexicalTag NON
ThesaurusID NLM (1993); Endopeptidase-24.11
Term UI T044804
Date03/18/1992
LexicalTag NON
ThesaurusID NLM (1993); CALLA Antigen
Term UI T458809
Date08/24/2001
LexicalTag ABB
ThesaurusID NLM (2003)

Neprilysin MeSH Descriptor Data 2024