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A family of structurally-related tyrosine kinase receptors that are expressed predominantly in ENDOTHELIAL CELLS and are essential for development of BLOOD VESSELS (NEOVASCULARIZATION, PHYSIOLOGIC). The name derives from the fact that they are tyrosine kinases that contain Ig and EGF domains.
Entry Version
RECEPT TIE
Entry Term(s)
Receptor Tyrosine Kinase TIE
TIE Receptor
TIE Receptor Family
TIE Receptor Tyrosine Kinase
TIE Receptor Tyrosine Kinases
Registry Numbers
EC 2.7.10.1
Previous Indexing
Receptor Protein-Tyrosine Kinases (1994-2003)
Receptors, Cell Surface (1992-1993)
Public MeSH Note
2004; TIE RECEPTOR TYROSINE KINASES (now RECEPTORS, TIE) was indexed under RECEPTOR PROTEIN-TYROSINE KINASES 1994-2003; under RECEPTORS, CELL SURFACE & PROTEIN-TYROSINE KINASE 1992-1993
A family of structurally-related tyrosine kinase receptors that are expressed predominantly in ENDOTHELIAL CELLS and are essential for development of BLOOD VESSELS (NEOVASCULARIZATION, PHYSIOLOGIC). The name derives from the fact that they are tyrosine kinases that contain Ig and EGF domains.