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Tumor Necrosis Factor-alpha MeSH Descriptor Data 2023


MeSH Heading
Tumor Necrosis Factor-alpha
Tree Number(s)
D12.644.276.374.500.800
D12.644.276.374.750.626
D12.776.124.900
D12.776.395.930
D12.776.467.374.500.800
D12.776.467.374.750.626
D23.529.374.500.800
D23.529.374.750.626
Unique ID
D014409
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D014409
Scope Note
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Entry Term(s)
Cachectin
Cachectin-Tumor Necrosis Factor
TNF Superfamily, Member 2
TNF-alpha
TNFalpha
Tumor Necrosis Factor
Tumor Necrosis Factor Ligand Superfamily Member 2
Registry Number
0
Previous Indexing
Endotoxins (1975-1987)
Glycoproteins (1975-1987)
Necrosis (1975-1987)
See Also
Adalimumab
Certolizumab Pegol
Infliximab
Public MeSH Note
2005; see TUMOR NECROSIS FACTOR 1988-2005
History Note
2005(1988)
Date Established
1988/01/01
Date of Entry
1987/05/08
Revision Date
2017/06/20
Tumor Necrosis Factor-alpha Preferred
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