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Ectodysplasins MeSH Descriptor Data 2022


MeSH Heading
Ectodysplasins
Tree Number(s)
D12.644.276.374.750.186
D12.776.395.550.275
D12.776.467.374.750.186
D12.776.543.550.275
D23.529.374.750.186
Unique ID
D053331
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D053331
Scope Note
Transmembrane proteins belonging to the tumor necrosis factor superfamily that play an essential role in the normal development of several ectodermally derived organs. Several isoforms of the ectodysplasins exist due to multiple ALTERNATIVE SPLICING of the MRNA for the protein. The isoforms ectodysplasin A1 and ectodysplasin A2 are considered biologically active and each bind distinct ECTODYSPLASIN RECEPTORS. Genetic mutations that result in loss of function of ectodysplasin result in ECTODERMAL DYSPLASIA 1, ANHIDROTIC.
Entry Term(s)
Ectodysplasin
Ectodysplasin A, Isoform 1
Ectodysplasin A, Isoform 2
Ectodysplasin A1
Ectodysplasin A2
Ectodysplasin-A
Registry Number
0
See Also
Ectodermal Dysplasia 1, Anhidrotic
Public MeSH Note
2007; ECTODYSPLASINS was indexed under MEMBRANE PROTEINS & TUMOR NECROSIS FACTORS 1998-2006
History Note
2007(1999)
Date Established
2007/01/01
Date of Entry
2006/07/05
Revision Date
2015/06/22
Ectodysplasins Preferred
Ectodysplasin A, Isoform 2 Narrower
Ectodysplasin A, Isoform 1 Narrower
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