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Thrombospondins MeSH Descriptor Data 2025


MeSH Heading
Thrombospondins
Tree Number(s)
D09.400.430.890.895
D12.776.395.550.895
D12.776.543.550.895
Unique ID
D019699
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D019699
Annotation
membrane glycoproteins; THROMBOSPONDIN 1 is also available
Scope Note
A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.
Entry Term(s)
Thrombospondin
Registry Numbers
0
Previous Indexing
Glycoproteins (1981-1989)
Membrane Glycoproteins (1989-1997)
Platelet Membrane Glycoproteins (1992-1993)
Public MeSH Note
98; THROMBOSPONDIN was indexed under MEMBRANE GLYCOPROTEINS 1989-97, PLATELET MEMBRANE GLYCOPROTEINS 1992-93, & GLYCOPROTEINS 1981-89
History Note
98; see THROMBOSPONDINS (NM) 1981-97
Date Established
1998/01/01
Date of Entry
1997/06/20
Revision Date
2023/03/16
Thrombospondins Preferred
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