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TNF-Related Apoptosis-Inducing Ligand MeSH Descriptor Data 2025
A transmembrane-protein belonging to the TNF family of intercellular signaling proteins. It is a widely expressed ligand that activates APOPTOSIS by binding to TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTORS. The membrane-bound form of the protein can be cleaved by specific CYSTEINE ENDOPEPTIDASES to form a soluble ligand form.
Entry Term(s)
Apo-2 Ligand
Apo-2L Protein
CD253 Antigen
TNF Superfamily, Member 10
TRAIL Protein
Tumor Necrosis Factor Ligand Superfamily Member 10
Registry Numbers
0
Public MeSH Note
2007; TNF-RELATED APOPTOSIS-INDUCING LIGAND was indexed under APOPTOSIS REGULATORY PROTEINS, TUMOR NECROSIS FACTOR-ALPHA and MEMBRANE GLYCOPROTEINS 1996-2006
A transmembrane-protein belonging to the TNF family of intercellular signaling proteins. It is a widely expressed ligand that activates APOPTOSIS by binding to TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTORS. The membrane-bound form of the protein can be cleaved by specific CYSTEINE ENDOPEPTIDASES to form a soluble ligand form.