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Cytokine TWEAK MeSH Descriptor Data 2022


MeSH Heading
Cytokine TWEAK
Tree Number(s)
D12.644.276.374.750.155
D12.776.467.374.750.155
D23.529.374.750.155
Unique ID
D000074049
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000074049
Scope Note
A proteolytically-cleaved membrane glycoprotein and member of the TNF superfamily that is highly expressed in a variety of tissues including heart, pancreas, brain, and peripheral blood lymphocytes. The secreted extracellular form is a weak inducer of APOPTOSIS for some cell types and a ligand for the FN14 RECEPTOR. It mediates activation of NF-KAPPA-B and promotes ANGIOGENESIS and proliferation of ENDOTHELIAL CELLS, as well as expression of cytokines involved in INFLAMMATION.
Entry Term(s)
Apo3 Ligand
TNF-Related Weak Inducer of Apoptosis
TWEAK Cytokine
Tumor Necrosis Factor Ligand Superfamily Member 12
Registry Number
0
Previous Indexing
Tumor Necrosis Factors (2006-2017)
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/02/24
Cytokine TWEAK Preferred
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