- Concept UI
- M000625319
- Registry Numbers
- 0
- Scope Note
- A proteolytically-cleaved membrane glycoprotein and member of the TNF superfamily that is highly expressed in a variety of tissues including heart, pancreas, brain, and peripheral blood lymphocytes. The secreted extracellular form is a weak inducer of APOPTOSIS for some cell types and a ligand for the FN14 RECEPTOR. It mediates activation of NF-KAPPA-B and promotes ANGIOGENESIS and proliferation of ENDOTHELIAL CELLS, as well as expression of cytokines involved in INFLAMMATION.
- Terms
-
Cytokine TWEAK
Preferred Term
Term UI
T000913796
Date01/06/2017
LexicalTag
ACX
ThesaurusID
NLM (2018)
-
Tumor Necrosis Factor Ligand Superfamily Member 12
Term UI
T000913792
Date01/06/2017
LexicalTag
NON
ThesaurusID
NLM (2018)
-
TNF-Related Weak Inducer of Apoptosis
Term UI
T000913793
Date01/06/2017
LexicalTag
ABX
ThesaurusID
NLM (2018)
-
Apo3 Ligand
Term UI
T000913794
Date01/06/2017
LexicalTag
ABX
ThesaurusID
NLM (2018)
-
TWEAK Cytokine
Term UI
T000915455
Date02/07/2017
LexicalTag
ACX
ThesaurusID
NLM (2018)