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Clozapine MeSH Descriptor Data 2022


MeSH Heading
Clozapine
Tree Number(s)
D03.633.300.240.220
Unique ID
D003024
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D003024
Scope Note
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Entry Term(s)
Clozaril
Leponex
Pharm Action
Serotonin Antagonists
Antipsychotic Agents
GABA Antagonists
Registry Number
J60AR2IKIC
Related Numbers
5786-21-0
CAS Type 1 Name
5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-
Previous Indexing
Dibenzazepines (1971-1974)
Piperazines (1971-1974)
Public MeSH Note
91; was see under DIBENZAZEPINES 1975-90
History Note
91(75); was see under DIBENZAZEPINES 1975-90
Date Established
1991/01/01
Date of Entry
1974/11/19
Revision Date
2016/05/28
Clozapine Preferred
Clozaril Narrower
Leponex Narrower
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