MeSH Browser

MeSH Heading: Desipramine
Tree Number(s): D03.633.300.240.281
Unique ID: D003891
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D003891
Scope Note: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
Entry Term(s): Apo-Desipramine; Demethylimipramine; Desipramine Hydrochloride; Desmethylimipramine; Norpramin; Novo-Desipramine; Nu-Desipramine; PMS-Desipramine; Pertofran; Pertofrane; Pertrofran; Petylyl; Ratio-Desipramine
Pharm Action: Antidepressive Agents, Tricyclic
Enzyme Inhibitors
Adrenergic Uptake Inhibitors
Related Numbers: 1Y58DO4MY1; 50-47-5; 58-28-6
CAS Type 1 Name: 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N-methyl-
NLM Classification #: QV 77.5
Public MeSH Note: 65
History Note: 65(63)
Date Established: 1965/01/01
Date of Entry: 1999/01/01
Revision Date: 2017/05/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0006074
Related Numbers: 1Y58DO4MY1; 50-47-5; 58-28-6
Scope Note: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
Terms: Desipramine Preferred Term
Term UI T011584
Date01/01/1999
LexicalTag NON
ThesaurusID; Demethylimipramine
Term UI T011583
Date07/31/1980
LexicalTag NON
ThesaurusID UNK (19XX); Desmethylimipramine
Term UI T011585
Date03/29/1974
LexicalTag NON
ThesaurusID UNK (19XX)

Desipramine MeSH Descriptor Data 2024