MeSH Browser

MeSH Heading: 7-Alkoxycoumarin O-Dealkylase
Tree Number(s): D08.811.682.690.708.170.010.024
Unique ID: D015660
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015660
Scope Note: A drug-metabolizing enzyme found in the hepatic, placental and intestinal microsomes that metabolizes 7-alkoxycoumarin to 7-hydroxycoumarin. The enzyme is cytochrome P-450- dependent.
Entry Term(s): 7-Ethoxycoumarin Dealkylase; 7-Ethoxycoumarin Hydroxylase; 7-Ethoxycoumarin Monooxygenase; 7-Ethoxycoumarin O-De-Ethylase; 7-Ethoxycoumarin O-Dealkylase; 7-Ethoxycoumarin O-Deethylase; 7-Propoxycoumarin O-Depropylase; Cytochrome P-450-Dependent O-Dealkylase; Ethoxycoumarin Deethylase; Ethoxycoumarin O-Deethylase
Previous Indexing: Oxygenases (1966-1989)
Public MeSH Note: 90
History Note: 90
Date Established: 1990/01/01
Date of Entry: 1989/05/25
Revision Date: 2016/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Aryl Hydrocarbon Hydroxylases [D08.811.682.690.708.170.010]
        
        7-Alkoxycoumarin O-Dealkylase [D08.811.682.690.708.170.010.024]
        
        Aniline Hydroxylase [D08.811.682.690.708.170.010.050]
        
        Benzopyrene Hydroxylase [D08.811.682.690.708.170.010.110]
        
        Cytochrome P-450 CYP1A1 [D08.811.682.690.708.170.010.277]
        
        Cytochrome P-450 CYP1A2 [D08.811.682.690.708.170.010.443]
        
        Cytochrome P-450 CYP1B1 [D08.811.682.690.708.170.010.500]
        
        Cytochrome P-450 CYP2B1 [D08.811.682.690.708.170.010.550]
        
        Cytochrome P-450 CYP2B6 [D08.811.682.690.708.170.010.575]
        
        Cytochrome P-450 CYP2C8 [D08.811.682.690.708.170.010.590]
        
        Cytochrome P-450 CYP2D6 [D08.811.682.690.708.170.010.600]

7-Alkoxycoumarin O-Dealkylase Preferred

Concept UI: M0023999
Scope Note: A drug-metabolizing enzyme found in the hepatic, placental and intestinal microsomes that metabolizes 7-alkoxycoumarin to 7-hydroxycoumarin. The enzyme is cytochrome P-450- dependent.
Terms: 7-Alkoxycoumarin O-Dealkylase Preferred Term
Term UI T046329
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1990); 7-Ethoxycoumarin Dealkylase
Term UI T046330
Date02/03/1989
LexicalTag NON
ThesaurusID NLM (1990); 7-Ethoxycoumarin Hydroxylase
Term UI T046331
Date02/03/1989
LexicalTag NON
ThesaurusID NLM (1990); 7-Ethoxycoumarin Monooxygenase
Term UI T046332
Date02/03/1989
LexicalTag NON
ThesaurusID NLM (1990); 7-Ethoxycoumarin O-Deethylase
Term UI T046333
Date02/03/1989
LexicalTag NON
ThesaurusID NLM (1990); 7-Ethoxycoumarin O-Dealkylase
Term UI T046334
Date02/03/1989
LexicalTag NON
ThesaurusID NLM (1990); 7-Propoxycoumarin O-Depropylase
Term UI T046335
Date02/03/1989
LexicalTag NON
ThesaurusID NLM (1990); Cytochrome P-450-Dependent O-Dealkylase
Term UI T046336
Date02/03/1989
LexicalTag NON
ThesaurusID NLM (1990); Ethoxycoumarin Deethylase
Term UI T046337
Date02/03/1989
LexicalTag NON
ThesaurusID NLM (1990); 7-Ethoxycoumarin O-De-Ethylase
Term UI T046338
Date02/03/1989
LexicalTag NON
ThesaurusID NLM (1990); Ethoxycoumarin O-Deethylase
Term UI T046339
Date02/03/1989
LexicalTag NON
ThesaurusID NLM (1990)

7-Alkoxycoumarin O-Dealkylase MeSH Descriptor Data 2024