MeSH Browser

MeSH Heading: Cytochrome P-450 CYP1A1
Tree Number(s): D08.244.453.005.332; D08.244.453.100.500; D08.811.682.690.708.170.010.277; D08.811.682.690.708.170.020.500; D12.776.422.220.453.010.332; D12.776.422.220.453.100.500
Unique ID: D019363
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D019363
Annotation: do not confuse with other cytochrome P-450 CYP's
Scope Note: A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. They have been found in mammals and fish. This enzyme, encoded by CYP1A1 gene, can be measured by using ethoxyresorufin as a substrate for the ethoxyresorufin O-deethylase activity.
Entry Term(s): 7-Ethoxyresorufin O-Deethylase; CYP 1A1; CYP1A1; CYP1A1 Protein; Cytochrome P450 IA1; EROD; Ethoxyresorufin Dealkylase; Ethoxyresorufin O-Deethylase; Ethylresorufin O-Deethylase
Registry Number: EC 1.14.14.1
Previous Indexing: Cytochrome P-450 (1982-1996); Oxazines (1979-1981); Oxidoreductases (1980-1996)
Public MeSH Note: 97; ETHOXYRESORUFIN O-DEETHYLASE was indexed under CYTOCHROME P-450 1982-96, OXIDOREDUCTASES 1980-96, & OXAZINES 1979-81
Online Note: use CYTOCHROME P-450 CYP1A1 (NM) to search ETHOXYRESORUFIN O-DEETHYLASE 1980-96
History Note: 97; was ETHOXYRESORUFIN O-DEETHYLASE (NM) 1979-96
Date Established: 1997/01/01
Date of Entry: 1996/06/24
Revision Date: 2016/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Cytochromes [D08.244]
  - Cytochrome P-450 Enzyme System [D08.244.453]
    - Aryl Hydrocarbon Hydroxylases [D08.244.453.005]

Enzymes and Coenzymes [D08]
- Cytochromes [D08.244]
  - Cytochrome P-450 Enzyme System [D08.244.453]
    - Cytochrome P450 Family 1 [D08.244.453.100]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Aryl Hydrocarbon Hydroxylases [D08.811.682.690.708.170.010]
        
        7-Alkoxycoumarin O-Dealkylase [D08.811.682.690.708.170.010.024]
        
        Aniline Hydroxylase [D08.811.682.690.708.170.010.050]
        
        Benzopyrene Hydroxylase [D08.811.682.690.708.170.010.110]
        
        Cytochrome P-450 CYP1A1 [D08.811.682.690.708.170.010.277]
        
        Cytochrome P-450 CYP1A2 [D08.811.682.690.708.170.010.443]
        
        Cytochrome P-450 CYP1B1 [D08.811.682.690.708.170.010.500]
        
        Cytochrome P-450 CYP2B1 [D08.811.682.690.708.170.010.550]
        
        Cytochrome P-450 CYP2B6 [D08.811.682.690.708.170.010.575]
        
        Cytochrome P-450 CYP2C8 [D08.811.682.690.708.170.010.590]
        
        Cytochrome P-450 CYP2D6 [D08.811.682.690.708.170.010.600]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Cytochrome P450 Family 1 [D08.811.682.690.708.170.020]
        
        Cytochrome P-450 CYP1A1 [D08.811.682.690.708.170.020.500]
        
        Cytochrome P-450 CYP1A2 [D08.811.682.690.708.170.020.750]
        
        Cytochrome P-450 CYP1B1 [D08.811.682.690.708.170.020.875]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Hemeproteins [D12.776.422]
    - Cytochromes [D12.776.422.220]
      - Cytochrome P-450 Enzyme System [D12.776.422.220.453]
        
        Aryl Hydrocarbon Hydroxylases [D12.776.422.220.453.010]
        
        Aniline Hydroxylase [D12.776.422.220.453.010.050]
        
        Benzopyrene Hydroxylase [D12.776.422.220.453.010.110]
        
        Cytochrome P-450 CYP1A1 [D12.776.422.220.453.010.332]
        
        Cytochrome P-450 CYP1A2 [D12.776.422.220.453.010.443]
        
        Cytochrome P-450 CYP1B1 [D12.776.422.220.453.010.500]
        
        Cytochrome P-450 CYP2B1 [D12.776.422.220.453.010.550]
        
        Cytochrome P-450 CYP2B6 [D12.776.422.220.453.010.575]
        
        Cytochrome P-450 CYP2C8 [D12.776.422.220.453.010.590]
        
        Cytochrome P-450 CYP2D6 [D12.776.422.220.453.010.600]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Hemeproteins [D12.776.422]
    - Cytochromes [D12.776.422.220]
      - Cytochrome P-450 Enzyme System [D12.776.422.220.453]
        
        Cytochrome P450 Family 1 [D12.776.422.220.453.100]
        
        Cytochrome P-450 CYP1A1 [D12.776.422.220.453.100.500]
        
        Cytochrome P-450 CYP1A2 [D12.776.422.220.453.100.750]
        
        Cytochrome P-450 CYP1B1 [D12.776.422.220.453.100.875]

Cytochrome P-450 CYP1A1 Preferred

Concept UI: M0028818
Registry Number: EC 1.14.14.1
Scope Note: A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. They have been found in mammals and fish. This enzyme, encoded by CYP1A1 gene, can be measured by using ethoxyresorufin as a substrate for the ethoxyresorufin O-deethylase activity.
Terms: Cytochrome P-450 CYP1A1 Preferred Term
Term UI T057709
Date01/01/1999
LexicalTag ABX
ThesaurusID NLM (1997); EROD
Term UI T057705
Date01/30/1996
LexicalTag ABB
ThesaurusID NLM (1997); Ethoxyresorufin Dealkylase
Term UI T057706
Date01/30/1996
LexicalTag NON
ThesaurusID NLM (1997); Ethylresorufin O-Deethylase
Term UI T057707
Date01/30/1996
LexicalTag NON
ThesaurusID NLM (1997); CYP1A1 Protein
Term UI T485570
Date03/13/2002
LexicalTag ABX
ThesaurusID NLM (2003); 7-Ethoxyresorufin O-Deethylase
Term UI T057710
Date01/30/1996
LexicalTag NON
ThesaurusID NLM (1997); CYP1A1
Term UI T057711
Date02/22/1996
LexicalTag ABB
ThesaurusID NLM (1997); Cytochrome P450 IA1
Term UI T057712
Date01/30/1996
LexicalTag NON
ThesaurusID NLM (1997); Ethoxyresorufin O-Deethylase
Term UI T057704
Date02/07/1996
LexicalTag NON
ThesaurusID NLM (1997); CYP 1A1
Term UI T057708
Date02/22/1996
LexicalTag ABB
ThesaurusID NLM (1997)

Cytochrome P-450 CYP1A1 MeSH Descriptor Data 2024