Cytochrome P-450 CYP2C8 MeSH Descriptor Data 2024

MeSH Heading: Cytochrome P-450 CYP2C8
Tree Number(s): D08.244.453.005.590; D08.244.453.491.368; D08.811.682.690.708.170.010.590; D08.811.682.690.708.170.450.360; D12.776.422.220.453.010.590; D12.776.422.220.453.491.360
Unique ID: D065727
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D065727
Scope Note: A liver microsomal cytochrome P450 hydroxylase that oxidizes a broad spectrum of substrates including STEROIDS, FATTY ACIDS, and XENOBIOTICS. Examples of pharmaceutical substrates for CYP2C8 include; PACLITAXOL; torsemide; and; AMODIAQUINE
Entry Term(s): CYP2C8; CYPIIC8; Cytochrome P450 MP-20; Cytochrome P450, Family 2, Subfamily C, Polypeptide 8; S-Mephenytoin 4-Hydroxylase
Previous Indexing: Aryl Hydrocarbon Hydroxylases (2002-2014)
Public MeSH Note: 2015
History Note: 2015
Entry Combination: antagonists & inhibitors:Cytochrome P-450 CYP2C8 Inhibitors
Date Established: 2015/01/01
Date of Entry: 2014/06/26
Revision Date: 2016/05/27

Entry Combination: antagonists & inhibitors:Cytochrome P-450 CYP2C8 Inhibitors
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Cytochromes [D08.244]
  - Cytochrome P-450 Enzyme System [D08.244.453]
    - Aryl Hydrocarbon Hydroxylases [D08.244.453.005]

Enzymes and Coenzymes [D08]
- Cytochromes [D08.244]
  - Cytochrome P-450 Enzyme System [D08.244.453]
    - Cytochrome P450 Family 2 [D08.244.453.491]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Aryl Hydrocarbon Hydroxylases [D08.811.682.690.708.170.010]
        
        7-Alkoxycoumarin O-Dealkylase [D08.811.682.690.708.170.010.024]
        
        Aniline Hydroxylase [D08.811.682.690.708.170.010.050]
        
        Benzopyrene Hydroxylase [D08.811.682.690.708.170.010.110]
        
        Cytochrome P-450 CYP1A1 [D08.811.682.690.708.170.010.277]
        
        Cytochrome P-450 CYP1A2 [D08.811.682.690.708.170.010.443]
        
        Cytochrome P-450 CYP1B1 [D08.811.682.690.708.170.010.500]
        
        Cytochrome P-450 CYP2B1 [D08.811.682.690.708.170.010.550]
        
        Cytochrome P-450 CYP2B6 [D08.811.682.690.708.170.010.575]
        
        Cytochrome P-450 CYP2C8 [D08.811.682.690.708.170.010.590]
        
        Cytochrome P-450 CYP2D6 [D08.811.682.690.708.170.010.600]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Cytochrome P450 Family 2 [D08.811.682.690.708.170.450]
        
        Cytochrome P-450 CYP2A6 [D08.811.682.690.708.170.450.250]
        
        Cytochrome P-450 CYP2B1 [D08.811.682.690.708.170.450.313]
        
        Cytochrome P-450 CYP2B6 [D08.811.682.690.708.170.450.344]
        
        Cytochrome P-450 CYP2C8 [D08.811.682.690.708.170.450.360]
        
        Cytochrome P-450 CYP2D6 [D08.811.682.690.708.170.450.368]
        
        Cytochrome P-450 CYP2E1 [D08.811.682.690.708.170.450.375]
        
        Limonene Hydroxylases [D08.811.682.690.708.170.450.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Hemeproteins [D12.776.422]
    - Cytochromes [D12.776.422.220]
      - Cytochrome P-450 Enzyme System [D12.776.422.220.453]
        
        Aryl Hydrocarbon Hydroxylases [D12.776.422.220.453.010]
        
        Aniline Hydroxylase [D12.776.422.220.453.010.050]
        
        Benzopyrene Hydroxylase [D12.776.422.220.453.010.110]
        
        Cytochrome P-450 CYP1A1 [D12.776.422.220.453.010.332]
        
        Cytochrome P-450 CYP1A2 [D12.776.422.220.453.010.443]
        
        Cytochrome P-450 CYP1B1 [D12.776.422.220.453.010.500]
        
        Cytochrome P-450 CYP2B1 [D12.776.422.220.453.010.550]
        
        Cytochrome P-450 CYP2B6 [D12.776.422.220.453.010.575]
        
        Cytochrome P-450 CYP2C8 [D12.776.422.220.453.010.590]
        
        Cytochrome P-450 CYP2D6 [D12.776.422.220.453.010.600]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Hemeproteins [D12.776.422]
    - Cytochromes [D12.776.422.220]
      - Cytochrome P-450 Enzyme System [D12.776.422.220.453]
        
        Cytochrome P450 Family 2 [D12.776.422.220.453.491]
        
        Cytochrome P-450 CYP2A6 [D12.776.422.220.453.491.250]
        
        Cytochrome P-450 CYP2B1 [D12.776.422.220.453.491.313]
        
        Cytochrome P-450 CYP2B6 [D12.776.422.220.453.491.344]
        
        Cytochrome P-450 CYP2C8 [D12.776.422.220.453.491.360]
        
        Cytochrome P-450 CYP2D6 [D12.776.422.220.453.491.368]
        
        Cytochrome P-450 CYP2E1 [D12.776.422.220.453.491.375]
        
        Limonene Hydroxylases [D12.776.422.220.453.491.500]

Cytochrome P-450 CYP2C8 Preferred

Concept UI: M0590595
Scope Note: A liver microsomal cytochrome P450 hydroxylase that oxidizes a broad spectrum of substrates including STEROIDS, FATTY ACIDS, and XENOBIOTICS. Examples of pharmaceutical substrates for CYP2C8 include; PACLITAXOL; torsemide; and; AMODIAQUINE
Terms: Cytochrome P-450 CYP2C8 Preferred Term
Term UI T853793
Date01/17/2014
LexicalTag ABX
ThesaurusID NLM (2015); CYP2C8
Term UI T853794
Date01/17/2014
LexicalTag ABB
ThesaurusID NLM (2015); CYPIIC8
Term UI T853795
Date01/17/2014
LexicalTag ABX
ThesaurusID NLM (2015); Cytochrome P450, Family 2, Subfamily C, Polypeptide 8
Term UI T853796
Date01/17/2014
LexicalTag NON
ThesaurusID NLM (2015); S-Mephenytoin 4-Hydroxylase
Term UI T853797
Date01/17/2014
LexicalTag NON
ThesaurusID NLM (2015); Cytochrome P450 MP-20
Term UI T853798
Date01/17/2014
LexicalTag ABX
ThesaurusID NLM (2015)

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