MeSH Browser

MeSH Heading: Single-Chain Antibodies
Tree Number(s): D12.644.541.500.650.500.800; D12.776.124.486.485.114.224.785; D12.776.124.486.485.680.650.500.800; D12.776.124.790.651.680.650.500.800; D12.776.377.715.548.680.650.500.795
Unique ID: D057127
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D057127
Scope Note: A form of antibodies consisting only of the variable regions of the heavy and light chains (FV FRAGMENTS), connected by a small linker peptide. They are less immunogenic than complete immunoglobulin and thus have potential therapeutic use.
Entry Term(s): Fv Antibody Fragments, Single-Chain; ScFv Antibodies; Single-Chain Fv; Single-Chain Fv Antibody; Single-Chain Fv Antibody Fragments; Single-Chain Variable Fragment; Single-Chain Variable Fragment Antibodies; Single-Chain Variable Fragment Antibody; Single-Chain Variable Fragments
Previous Indexing: Antibodies or specifics (1990-2009); Immunoglobulin Fragments (1992-2009); Immunoglobulin Variable Region (1993-2009)
See Also: Single-Domain Antibodies
Public MeSH Note: 2010
History Note: 2010
Date Established: 2010/01/01
Date of Entry: 2009/07/06
Revision Date: 2012/07/03

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Peptide Fragments [D12.644.541]
    - Immunoglobulin Fragments [D12.644.541.500]
      - Immunoglobulin Fab Fragments [D12.644.541.500.650]
        
        Immunoglobulin Variable Region [D12.644.541.500.650.500]
        
        Complementarity Determining Regions [D12.644.541.500.650.500.180]
        
        Immunoglobulin Joining Region [D12.644.541.500.650.500.590]
        
        Single-Chain Antibodies [D12.644.541.500.650.500.800]
        
        Single-Domain Antibodies [D12.644.541.500.650.500.900]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Immunoproteins [D12.776.124.486]
      - Immunoglobulins [D12.776.124.486.485]
        
        Antibodies [D12.776.124.486.485.114]
        
        Antibodies, Monoclonal [D12.776.124.486.485.114.224]
        
        Antibodies, Monoclonal, Humanized [D12.776.124.486.485.114.224.060]
        
        Antibodies, Monoclonal, Murine-Derived [D12.776.124.486.485.114.224.075]
        
        Combined Antibody Therapeutics [D12.776.124.486.485.114.224.342]
        
        Infliximab [D12.776.124.486.485.114.224.608]
        
        Single-Chain Antibodies [D12.776.124.486.485.114.224.785]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Immunoproteins [D12.776.124.486]
      - Immunoglobulins [D12.776.124.486.485]
        
        Immunoglobulin Fragments [D12.776.124.486.485.680]
        
        Immunoglobulin Fab Fragments [D12.776.124.486.485.680.650]
        
        Immunoglobulin Variable Region [D12.776.124.486.485.680.650.500]
        
        Complementarity Determining Regions [D12.776.124.486.485.680.650.500.180]
        
        Immunoglobulin Joining Region [D12.776.124.486.485.680.650.500.590]
        
        Single-Chain Antibodies [D12.776.124.486.485.680.650.500.800]
        
        Single-Domain Antibodies [D12.776.124.486.485.680.650.500.900]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Serum Globulins [D12.776.124.790]
      - Immunoglobulins [D12.776.124.790.651]
        
        Immunoglobulin Fragments [D12.776.124.790.651.680]
        
        Immunoglobulin Fab Fragments [D12.776.124.790.651.680.650]
        
        Immunoglobulin Variable Region [D12.776.124.790.651.680.650.500]
        
        Complementarity Determining Regions [D12.776.124.790.651.680.650.500.180]
        
        Immunoglobulin Joining Region [D12.776.124.790.651.680.650.500.590]
        
        Single-Chain Antibodies [D12.776.124.790.651.680.650.500.800]
        
        Single-Domain Antibodies [D12.776.124.790.651.680.650.500.900]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Globulins [D12.776.377]
    - Serum Globulins [D12.776.377.715]
      - Immunoglobulins [D12.776.377.715.548]
        
        Immunoglobulin Fragments [D12.776.377.715.548.680]
        
        Immunoglobulin Fab Fragments [D12.776.377.715.548.680.650]
        
        Immunoglobulin Variable Region [D12.776.377.715.548.680.650.500]
        
        Complementarity Determining Regions [D12.776.377.715.548.680.650.500.180]
        
        Immunoglobulin Joining Region [D12.776.377.715.548.680.650.500.590]
        
        Single-Chain Antibodies [D12.776.377.715.548.680.650.500.795]
        
        Single-Domain Antibodies [D12.776.377.715.548.680.650.500.897]

Single-Chain Antibodies Preferred

Concept UI: M0534715
Scope Note: A form of antibodies consisting only of the variable regions of the heavy and light chains (FV FRAGMENTS), connected by a small linker peptide. They are less immunogenic than complete immunoglobulin and thus have potential therapeutic use.
Terms: Single-Chain Antibodies Preferred Term
Term UI T749385
Date04/15/2009
LexicalTag NON
ThesaurusID NLM (2010); ScFv Antibodies
Term UI T750745
Date05/07/2009
LexicalTag ABX
ThesaurusID NLM (2010); Single-Chain Fv
Term UI T758883
Date10/02/2009
LexicalTag ABX
ThesaurusID NLM (2011); Single-Chain Fv Antibody
Term UI T758882
Date10/02/2009
LexicalTag ABX
ThesaurusID NLM (2011); Single-Chain Fv Antibody Fragments
Term UI T796235
Date08/30/2011
LexicalTag NON
ThesaurusID NLM (2013); Fv Antibody Fragments, Single-Chain
Term UI T796236
Date08/30/2011
LexicalTag NON
ThesaurusID NLM (2013); Single-Chain Variable Fragment Antibodies
Term UI T750743
Date05/07/2009
LexicalTag NON
ThesaurusID NLM (2010); Single-Chain Variable Fragment Antibody
Term UI T758881
Date10/02/2009
LexicalTag NON
ThesaurusID NLM (2011); Single-Chain Variable Fragments
Term UI T750744
Date05/07/2009
LexicalTag NON
ThesaurusID NLM (2010); Single-Chain Variable Fragment
Term UI T758880
Date10/02/2009
LexicalTag NON
ThesaurusID NLM (2011)

Single-Chain Antibodies MeSH Descriptor Data 2024