Single-Domain Antibodies MeSH Descriptor Data 2024

MeSH Heading: Single-Domain Antibodies
Tree Number(s): D12.644.541.500.650.500.900; D12.776.124.486.485.680.650.500.900; D12.776.124.790.651.680.650.500.900; D12.776.377.715.548.680.650.500.897
Unique ID: D061905
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D061905
Scope Note: An immunoglobulin fragment composed of one variable domain from an IMMUNOGLOBULIN HEAVY CHAIN or IMMUNOGLOBULIN LIGHT CHAIN.
Entry Term(s): Immunoglobulin VH Domain Fragments; Immunoglobulin VL Domain Fragments; Nanobodies; Single-Domain Antibody; VH Domain Fragments; VHH Antibodies; VHH Antibody; VHH Fragments; VHH Immunoglobulin Fragments; VL Domain Fragments; VNAR Fragments; VNAR Immunoglobulin Fragments
See Also: Single-Chain Antibodies
Public MeSH Note: 2013
History Note: 2013
Date Established: 2013/01/01
Date of Entry: 2012/07/03
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Peptide Fragments [D12.644.541]
    - Immunoglobulin Fragments [D12.644.541.500]
      - Immunoglobulin Fab Fragments [D12.644.541.500.650]
        
        Immunoglobulin Variable Region [D12.644.541.500.650.500]
        
        Complementarity Determining Regions [D12.644.541.500.650.500.180]
        
        Immunoglobulin Joining Region [D12.644.541.500.650.500.590]
        
        Single-Chain Antibodies [D12.644.541.500.650.500.800]
        
        Single-Domain Antibodies [D12.644.541.500.650.500.900]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Immunoproteins [D12.776.124.486]
      - Immunoglobulins [D12.776.124.486.485]
        
        Immunoglobulin Fragments [D12.776.124.486.485.680]
        
        Immunoglobulin Fab Fragments [D12.776.124.486.485.680.650]
        
        Immunoglobulin Variable Region [D12.776.124.486.485.680.650.500]
        
        Complementarity Determining Regions [D12.776.124.486.485.680.650.500.180]
        
        Immunoglobulin Joining Region [D12.776.124.486.485.680.650.500.590]
        
        Single-Chain Antibodies [D12.776.124.486.485.680.650.500.800]
        
        Single-Domain Antibodies [D12.776.124.486.485.680.650.500.900]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Serum Globulins [D12.776.124.790]
      - Immunoglobulins [D12.776.124.790.651]
        
        Immunoglobulin Fragments [D12.776.124.790.651.680]
        
        Immunoglobulin Fab Fragments [D12.776.124.790.651.680.650]
        
        Immunoglobulin Variable Region [D12.776.124.790.651.680.650.500]
        
        Complementarity Determining Regions [D12.776.124.790.651.680.650.500.180]
        
        Immunoglobulin Joining Region [D12.776.124.790.651.680.650.500.590]
        
        Single-Chain Antibodies [D12.776.124.790.651.680.650.500.800]
        
        Single-Domain Antibodies [D12.776.124.790.651.680.650.500.900]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Globulins [D12.776.377]
    - Serum Globulins [D12.776.377.715]
      - Immunoglobulins [D12.776.377.715.548]
        
        Immunoglobulin Fragments [D12.776.377.715.548.680]
        
        Immunoglobulin Fab Fragments [D12.776.377.715.548.680.650]
        
        Immunoglobulin Variable Region [D12.776.377.715.548.680.650.500]
        
        Complementarity Determining Regions [D12.776.377.715.548.680.650.500.180]
        
        Immunoglobulin Joining Region [D12.776.377.715.548.680.650.500.590]
        
        Single-Chain Antibodies [D12.776.377.715.548.680.650.500.795]
        
        Single-Domain Antibodies [D12.776.377.715.548.680.650.500.897]

Single-Domain Antibodies Preferred

VHH Immunoglobulin Fragments Narrower

Concept UI: M0560656
Scope Note: An immunoglobulin fragment composed of one variable domain from an IMMUNOGLOBULIN HEAVY CHAIN from the serum of camelids (ALPACAS, LLAMAS, CAMELS, and DROMEDARY).
Terms: VHH Immunoglobulin Fragments Preferred Term
Term UI T796276
Date08/31/2011
LexicalTag NON
ThesaurusID NLM (2013); VHH Antibody
Term UI T001080012
Date05/10/2020
LexicalTag ABX
ThesaurusID NLM (2021); VHH Fragments
Term UI T796277
Date08/31/2011
LexicalTag ABX
ThesaurusID NLM (2013); Nanobodies
Term UI T796278
Date08/31/2011
LexicalTag NON
ThesaurusID NLM (2013); VHH Antibodies
Term UI T001080010
Date05/10/2020
LexicalTag NON
ThesaurusID NLM (2021)

VNAR Immunoglobulin Fragments Narrower

Immunoglobulin VH Domain Fragments Narrower

Immunoglobulin VL Domain Fragments Narrower

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