MeSH Browser

MeSH Heading: Immunoglobulin Variable Region
Tree Number(s): D12.644.541.500.650.500; D12.776.124.486.485.680.650.500; D12.776.124.486.485.797; D12.776.124.790.651.680.650.500; D12.776.124.790.651.797; D12.776.377.715.548.680.650.500; D12.776.377.715.548.797; G02.111.570.060.425
Unique ID: D007135
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D007135
Scope Note: That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions.
Entry Term(s): Framework Region, Immunoglobulin; Fv Antibody Fragments; Fv Fragments; Ig Framework Region; Ig Variable Region; Immunoglobulin Framework Region; Immunoglobulin Fv Fragments; Immunoglobulin V; Variable Region, Ig; Variable Region, Immunoglobulin
Pharm Action: Immunologic Factors
Registry Numbers: 0
Previous Indexing: Antigenic Determinants (1972-1976); Binding Sites, Antibody (1973-1976); Immunoglobulin Fragments (1973-1976); Immunoglobulins, Fab (1973-1976)
See Also: Binding Sites, Antibody; Immunoglobulin Domains
Public MeSH Note: 84; was see under BINDING SITES, ANTIBODY 1977-83
History Note: 84(77); was see under BINDING SITES, ANTIBODY 1977-83
Date Established: 1984/01/01
Date of Entry: 1976/04/16
Revision Date: 2015/11/20

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Peptide Fragments [D12.644.541]
    - Immunoglobulin Fragments [D12.644.541.500]
      - Immunoglobulin Fab Fragments [D12.644.541.500.650]
        
        Abciximab [D12.644.541.500.650.125]
        
        Certolizumab Pegol [D12.644.541.500.650.250]
        
        Immunoglobulin Variable Region [D12.644.541.500.650.500]
        
        Complementarity Determining Regions [D12.644.541.500.650.500.180]
        
        Immunoglobulin Joining Region [D12.644.541.500.650.500.590]
        
        Single-Chain Antibodies [D12.644.541.500.650.500.800]
        
        Single-Domain Antibodies [D12.644.541.500.650.500.900]
        
        Tuftsin [D12.644.541.500.650.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Immunoproteins [D12.776.124.486]
      - Immunoglobulins [D12.776.124.486.485]
        
        Immunoglobulin Fragments [D12.776.124.486.485.680]
        
        Immunoglobulin Fab Fragments [D12.776.124.486.485.680.650]
        
        Abciximab [D12.776.124.486.485.680.650.125]
        
        Certolizumab Pegol [D12.776.124.486.485.680.650.250]
        
        Immunoglobulin Variable Region [D12.776.124.486.485.680.650.500]
        
        Complementarity Determining Regions [D12.776.124.486.485.680.650.500.180]
        
        Immunoglobulin Joining Region [D12.776.124.486.485.680.650.500.590]
        
        Single-Chain Antibodies [D12.776.124.486.485.680.650.500.800]
        
        Single-Domain Antibodies [D12.776.124.486.485.680.650.500.900]
        
        Tuftsin [D12.776.124.486.485.680.650.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Immunoproteins [D12.776.124.486]
      - Immunoglobulins [D12.776.124.486.485]
        
        Antibodies [D12.776.124.486.485.114]
        
        CD83 Antigen [D12.776.124.486.485.256]
        
        gamma-Globulins [D12.776.124.486.485.397]
        
        Immunoglobulin Constant Regions [D12.776.124.486.485.538]
        
        Immunoglobulin Fragments [D12.776.124.486.485.680]
        
        Immunoglobulin Subunits [D12.776.124.486.485.705]
        
        Immunoglobulin Variable Region [D12.776.124.486.485.797]
        
        Complementarity Determining Regions [D12.776.124.486.485.797.180]
        
        Immunoglobulin Joining Region [D12.776.124.486.485.797.590]
        
        Paraproteins [D12.776.124.486.485.900]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Serum Globulins [D12.776.124.790]
      - Immunoglobulins [D12.776.124.790.651]
        
        Immunoglobulin Fragments [D12.776.124.790.651.680]
        
        Immunoglobulin Fab Fragments [D12.776.124.790.651.680.650]
        
        Abciximab [D12.776.124.790.651.680.650.125]
        
        Certolizumab Pegol [D12.776.124.790.651.680.650.250]
        
        Immunoglobulin Variable Region [D12.776.124.790.651.680.650.500]
        
        Complementarity Determining Regions [D12.776.124.790.651.680.650.500.180]
        
        Immunoglobulin Joining Region [D12.776.124.790.651.680.650.500.590]
        
        Single-Chain Antibodies [D12.776.124.790.651.680.650.500.800]
        
        Single-Domain Antibodies [D12.776.124.790.651.680.650.500.900]
        
        Tuftsin [D12.776.124.790.651.680.650.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Serum Globulins [D12.776.124.790]
      - Immunoglobulins [D12.776.124.790.651]
        
        Antibodies [D12.776.124.790.651.114]
        
        CD83 Antigen [D12.776.124.790.651.256]
        
        gamma-Globulins [D12.776.124.790.651.397]
        
        Immunoglobulin Constant Regions [D12.776.124.790.651.538]
        
        Immunoglobulin Fragments [D12.776.124.790.651.680]
        
        Immunoglobulin Subunits [D12.776.124.790.651.705]
        
        Immunoglobulin Variable Region [D12.776.124.790.651.797]
        
        Complementarity Determining Regions [D12.776.124.790.651.797.180]
        
        Immunoglobulin Joining Region [D12.776.124.790.651.797.590]
        
        Paraproteins [D12.776.124.790.651.900]
        
        Receptors, Antigen, B-Cell [D12.776.124.790.651.950]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Globulins [D12.776.377]
    - Serum Globulins [D12.776.377.715]
      - Immunoglobulins [D12.776.377.715.548]
        
        Immunoglobulin Fragments [D12.776.377.715.548.680]
        
        Immunoglobulin Fab Fragments [D12.776.377.715.548.680.650]
        
        Abciximab [D12.776.377.715.548.680.650.125]
        
        Certolizumab Pegol [D12.776.377.715.548.680.650.250]
        
        Immunoglobulin Variable Region [D12.776.377.715.548.680.650.500]
        
        Complementarity Determining Regions [D12.776.377.715.548.680.650.500.180]
        
        Immunoglobulin Joining Region [D12.776.377.715.548.680.650.500.590]
        
        Single-Chain Antibodies [D12.776.377.715.548.680.650.500.795]
        
        Single-Domain Antibodies [D12.776.377.715.548.680.650.500.897]
        
        Tuftsin [D12.776.377.715.548.680.650.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Globulins [D12.776.377]
    - Serum Globulins [D12.776.377.715]
      - Immunoglobulins [D12.776.377.715.548]
        
        Antibodies [D12.776.377.715.548.114]
        
        CD83 Antigen [D12.776.377.715.548.256]
        
        gamma-Globulins [D12.776.377.715.548.397]
        
        Immunoglobulin Constant Regions [D12.776.377.715.548.538]
        
        Immunoglobulin Fragments [D12.776.377.715.548.680]
        
        Immunoglobulin Subunits [D12.776.377.715.548.705]
        
        Immunoglobulin Variable Region [D12.776.377.715.548.797]
        
        Complementarity Determining Regions [D12.776.377.715.548.797.180]
        
        Immunoglobulin Joining Region [D12.776.377.715.548.797.590]
        
        Paraproteins [D12.776.377.715.548.900]
        
        Receptors, Antigen, B-Cell [D12.776.377.715.548.950]

Chemical Phenomena [G02]
- Biochemical Phenomena [G02.111]
  - Molecular Structure [G02.111.570]
    - Amino Acid Sequence [G02.111.570.060]

Immunoglobulin Variable Region Preferred

Concept UI: M0011118
Registry Numbers: 0
Scope Note: That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions.
Terms: Immunoglobulin Variable Region Preferred Term
Term UI T021359
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1977); Variable Region, Immunoglobulin
Term UI T410411
Date03/27/2000
LexicalTag NON
ThesaurusID NLM (2001); Ig Variable Region
Term UI T643607
Date06/17/2005
LexicalTag NON
ThesaurusID NLM (2006); Immunoglobulin V
Term UI T021358
Date03/05/1984
LexicalTag NON
ThesaurusID UNK (19XX); Variable Region, Ig
Term UI T021361
Date04/14/1976
LexicalTag NON
ThesaurusID UNK (19XX)

Framework Region, Immunoglobulin Narrower

Immunoglobulin Fv Fragments Related

Immunoglobulin Variable Region MeSH Descriptor Data 2025