MeSH Browser

MeSH Heading: Intrinsically Disordered Proteins
Tree Number(s): D12.776.481
Unique ID: D064267
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D064267
Scope Note: Functional proteins that do not have unique, stable, folded, three-dimensional native structures or that possess non-ordered regions under physiological conditions. They are characterized by extraordinary structural flexibility and plasticity, which enable them to adopt different conformations in response to different stimuli or different interactions.
Entry Term(s): Intrinsically Disordered Protein; Natively Unfolded Protein; Natively Unfolded Proteins; Unstructured Protein; Unstructured Proteins
Registry Numbers: 0
NLM Classification #: QU 55
See Also: Protein Folding; Protein Unfolding
Public MeSH Note: 2014
History Note: 2014
Date Introduced: 2014/01/01
Last Updated: 2020/06/29

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0580703
Registry Numbers: 0
Scope Note: Functional proteins that do not have unique, stable, folded, three-dimensional native structures or that possess non-ordered regions under physiological conditions. They are characterized by extraordinary structural flexibility and plasticity, which enable them to adopt different conformations in response to different stimuli or different interactions.
Terms: Intrinsically Disordered Proteins Preferred Term
Term UI T836295
Date01/25/2013
LexicalTag NON
ThesaurusID NLM (2014); Intrinsically Disordered Protein
Term UI T000996236
Date11/14/2019
LexicalTag NON
ThesaurusID NLM (2021); Unstructured Proteins
Term UI T838649
Date03/15/2013
LexicalTag NON
ThesaurusID NLM (2014); Natively Unfolded Proteins
Term UI T838650
Date03/15/2013
LexicalTag NON
ThesaurusID NLM (2014); Natively Unfolded Protein
Term UI T001083688
Date06/29/2020
LexicalTag NON
ThesaurusID NLM (2021); Unstructured Protein
Term UI T001083689
Date06/29/2020
LexicalTag NON
ThesaurusID NLM (2021)

Intrinsically Disordered Proteins MeSH Descriptor Data 2026