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Receptor, Insulin MeSH Descriptor Data 2022


MeSH Heading
Receptor, Insulin
Tree Number(s)
D08.811.913.696.620.682.725.400.200
D12.776.476.568.400.200
D12.776.543.750.630.484
D12.776.543.750.750.580.300
Unique ID
D011972
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D011972
Scope Note
A cell surface receptor for INSULIN. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic TYROSINE KINASE domain that is located within the beta subunit. Activation of the receptor by INSULIN results in numerous metabolic changes including increased uptake of GLUCOSE into the liver, muscle, and ADIPOSE TISSUE.
Entry Version
RECEPT INSULIN
Entry Term(s)
Insulin Receptor
Insulin Receptor Protein-Tyrosine Kinase
Insulin Receptor alpha Chain
Insulin Receptor alpha Subunit
Insulin Receptor beta Chain
Insulin Receptor beta Subunit
Insulin-Dependent Tyrosine Protein Kinase
Receptors, Insulin
Registry Number
EC 2.7.10.1
NLM Classification #
WK 802
Previous Indexing
Insulin (1966-1976)
Receptors, Drug (1968-1976)
Receptors, Endogenous Substances (1973-1976)
See Also
Donohue Syndrome
Public MeSH Note
2000; for INSULIN RECEPTOR PROTEIN-TYROSINE KINASE see INSULIN RECEPTOR PROTEIN-TYROSINE KINASE 1994-1999; INSULIN-DEPENDENT PROTEIN TYROSINE KINASE was indexed under PROTEIN-TYROSINE KINASE 1986-1993 & PROTEIN KINASES 1983-1985
History Note
2000(1977); for INSULIN RECEPTOR PROTEIN-TYROSINE KINASE use RECEPTOR, INSULIN (NM) 1983-1993
Date Established
1977/01/01
Date of Entry
1976/05/03
Revision Date
2021/05/21
Receptor, Insulin Preferred
Insulin Receptor beta Subunit Narrower
Insulin Receptor alpha Subunit Narrower
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