MeSH Browser

MeSH Heading: Insulysin
Tree Number(s): D08.811.277.656.300.480.300; D08.811.277.656.675.374.300
Unique ID: D007339
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D007339
Scope Note: An enzyme the catalyzes the degradation of insulin, glucagon and other polypeptides. It is inhibited by bacitracin, chelating agents EDTA and 1,10-phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not phosphoramidon. (Eur J Biochem 1994;223:1-5) EC 3.4.24.56.
Entry Term(s): Insulin Protease; Insulin Proteinase; Insulin-Degrading Enzyme; Insulinase
Registry Numbers: EC 3.4.24.56
Public MeSH Note: 97; was INSULINASE 1963-96 (see under PEPTIDE HYDROLASES 1975-90, see under PEPTIDE PEPTIDOHYDROLASES 1963-74)
Online Note: search ENDOPEPTIDASES 1966-74
History Note: 97; was INSULINASE 1963-96 (see under PEPTIDE HYDROLASES 1975-90, see under ENDOPEPTIDASES 1963-74)
Date Established: 1991/01/01
Date of Entry: 1999/01/01
Revision Date: 2003/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0011443
Registry Numbers: EC 3.4.24.56
Scope Note: An enzyme the catalyzes the degradation of insulin, glucagon and other polypeptides. It is inhibited by bacitracin, chelating agents EDTA and 1,10-phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not phosphoramidon. (Eur J Biochem 1994;223:1-5) EC 3.4.24.56.
Terms: Insulysin Preferred Term
Term UI T021991
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975); Insulin Proteinase
Term UI T021987
Date08/12/1987
LexicalTag NON
ThesaurusID UNK (19XX); Insulin-Degrading Enzyme
Term UI T021988
Date11/24/1982
LexicalTag NON
ThesaurusID UNK (19XX); Insulinase
Term UI T021989
Date02/08/1996
LexicalTag NON
ThesaurusID NLM (1997); Insulin Protease
Term UI T021990
Date10/26/1981
LexicalTag NON
ThesaurusID UNK (19XX)

Insulysin MeSH Descriptor Data 2024